Methoxy-X04

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Cat.No. 4920 - Methoxy-X04 | C23H20O3 | CAS No. 863918-78-9
Description: Fluorescent amyloid β detector; brain penetrant
Chemical Name: 4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews (1)
Literature (2)

Biological Activity

Fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.

Technical Data

M. Wt 344.4
Formula C23H20O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 863918-78-9
PubChem ID 16049314
InChI Key FGYNZFHVGOFCMD-KHVHPYDTSA-N
Smiles OC(C=C3)=CC=C3/C=C/C1=CC(OC)=C(/C=C/C2=CC=C(O)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.44 100
ethanol 6.89 20

Preparing Stock Solutions

The following data is based on the product molecular weight 344.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.52 mL 29.04 mL
5 mM 0.58 mL 2.9 mL 5.81 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bolmont et al (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J.Neurosci. 28 4283 PMID: 18417708

Yamanaka et al (2012) PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J.Neurosci. 32 17321 PMID: 23197723

Klunk et al (2002) Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J.Neuropathol.Exp.Neurol. 61 797 PMID: 12230326


If you know of a relevant reference for Methoxy-X04, please let us know.

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6 Citations for Methoxy-X04

Citations are publications that use Tocris products. Selected citations for Methoxy-X04 include:

Medrano-Jimé nez et al (2019) Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism. J Neuroinflammation 16 143 PMID: 31291963

Ulland et al (2017) TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell 170 649 PMID: 28802038

Plog et al (2018) Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. JCI Insight 3 PMID: 30333324

Blume et al (2018) Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. J Neuroinflammation 15 307 PMID: 30400912

Möhle et al (2016) Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathol Commun 4 25 PMID: 26984535

Fu et al (2016) IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Elife 113 E2705 PMID: 27091974


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Reviews for Methoxy-X04

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Amyloid plaque labelling.
By Anonymous on 11/19/2018
Assay Type: In Vivo
Species: Mouse

Injected IV, Methoxy-X04 labels amyloid plaques in AD models. Great tool to image various cellular processes around AD plaques.


Literature in this Area

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