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Fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Brain penetrant.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 344.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.9 mL||14.52 mL||29.04 mL|
|5 mM||0.58 mL||2.9 mL||5.81 mL|
|10 mM||0.29 mL||1.45 mL||2.9 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the biological activity of the product.
Bolmont et al (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J.Neurosci. 28 4283 PMID: 18417708
Yamanaka et al (2012) PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J.Neurosci. 32 17321 PMID: 23197723
Klunk et al (2002) Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J.Neuropathol.Exp.Neurol. 61 797 PMID: 12230326
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Keywords: Methoxy-X04, Methoxy-X04 supplier, amyloid, beta, fluorescent, probes, detection, alzheimers, disease, brain, penetrant, blood, barrier, permeable, high, affinity, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, Peptides, Other, Fluorescent, Probes, 4920, Tocris Bioscience
6 Citations for Methoxy-X04
Citations are publications that use Tocris products. Selected citations for Methoxy-X04 include:
Medrano-Jimé nez et al (2019) Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-γ-dependent mechanism. J Neuroinflammation 16 143 PMID: 31291963
Ulland et al (2017) TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell 170 649 PMID: 28802038
Plog et al (2018) Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. JCI Insight 3 PMID: 30333324
Blume et al (2018) Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. J Neuroinflammation 15 307 PMID: 30400912
Möhle et al (2016) Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathol Commun 4 25 PMID: 26984535
Fu et al (2016) IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Elife 113 E2705 PMID: 27091974
Do you know of a great paper that uses Methoxy-X04 from Tocris? Please let us know.
Reviews for Methoxy-X04
Average Rating: 5 (Based on 1 Review.)
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Injected IV, Methoxy-X04 labels amyloid plaques in AD models. Great tool to image various cellular processes around AD plaques.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.