CGP 53353

Pricing Availability   Qty
Description: Selective inhibitor of PKCβII
Chemical Name: 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity for CGP 53353

CGP 53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.

Compound Libraries for CGP 53353

CGP 53353 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for CGP 53353

M. Wt 365.34
Formula C20H13F2N3O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 145915-60-2
PubChem ID 6711154
Smiles FC1=CC=C(NC2=CC3=C(C=C2NC2=CC=C(F)C=C2)C(=O)NC3=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CGP 53353

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.53 100
ethanol 7.31 20

Preparing Stock Solutions for CGP 53353

The following data is based on the product molecular weight 365.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.69 mL 27.37 mL
5 mM 0.55 mL 2.74 mL 5.47 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for CGP 53353

References are publications that support the biological activity of the product.

Kouroedov et al (2004) Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 110 91 PMID: 15210597

Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci.USA 105 7159

If you know of a relevant reference for CGP 53353, please let us know.

View Related Products by Product Action

View all Protein Kinase C Inhibitors

Keywords: CGP 53353, CGP 53353 supplier, Selective, inhibitors, inhibits, PKCbetaII, de, novo, Aβ4, β42, beta42, assesmbly, PKC, PKM, Protein, Kinase, C, Kinases, b-amyloid, β-Amyloid, beta-Amyloid, Precursor, APP, Secretase, beta, Peptides, prionogenic, Sup35, fibrillization, CGP53353, amyloidbeta, amyloidb, Amyloid, Beta, 2442, Tocris Bioscience

3 Citations for CGP 53353

Citations are publications that use Tocris products. Selected citations for CGP 53353 include:

Liu et al (2014) PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils. Mol Biol Cell 25 1446 PMID: 24600048

He et al (2011) Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells. J Neurosci 18 39 PMID: 21672207

Ramana et al (2007) Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology 148 4371 PMID: 17584970

Do you know of a great paper that uses CGP 53353 from Tocris? Please let us know.

Reviews for CGP 53353

There are currently no reviews for this product. Be the first to review CGP 53353 and earn rewards!

Have you used CGP 53353?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review