Selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 365.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.69 mL||27.37 mL|
|5 mM||0.55 mL||2.74 mL||5.47 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References are publications that support the biological activity of the product.
Kouroedov et al (2004) Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 110 91 PMID: 15210597
Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci.USA 105 7159
If you know of a relevant reference for CGP 53353, please let us know.
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Keywords: CGP 53353, CGP 53353 supplier, Selective, inhibitors, inhibits, PKCbetaII, de, novo, Aβ4, β42, beta42, assesmbly, PKC, PKM, Protein, Kinase, C, Kinases, b-amyloid, β-Amyloid, beta-Amyloid, Precursor, APP, Secretase, beta, Peptides, prionogenic, Sup35, fibrillization, CGP53353, amyloidbeta, amyloidb, Amyloid, Beta, 2442, Tocris Bioscience
3 Citations for CGP 53353
Citations are publications that use Tocris products. Selected citations for CGP 53353 include:
Liu et al (2014) PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils. Mol Biol Cell 25 1446 PMID: 24600048
He et al (2011) Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells. J Neurosci 18 39 PMID: 21672207
Ramana et al (2007) Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology 148 4371 PMID: 17584970
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Literature in this Area
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