Amyloid β Peptide Inhibitors

Cat. No.	Product Name / Activity
6363	Avagacestat
	Highly potent γ-secretase inhibitor; orally bioavailable
4283	Begacestat
	γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
2870	BMS 299897
	γ-secretase inhibitor; reduces Aβ levels
4924	CEP 1347
	Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling
3360	CGP 52411
	Inhibits Aβ42 fibril formation. Also EGFR inhibitor
2442	CGP 53353
	Inhibitor of de novo Aβ42 assembly
2654	Compound W
	γ-secretase inhibitor; reduces Aβ42 levels
2634	DAPT
	γ-secretase inhibitor; reduces Aβ42 levels
6779	Davunetide
	Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo
4524	EGCG
	β-secretase inhibitor; inhibits formation of amyloid fibrils
2677	JLK 6
	Inhibitor of γ-secretase-mediated βAPP processing
2627	L-685,458
	Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
7081	LY 2886721 Hydrochloride
	Inhibits Aβ1-40 and 1-42 production in vitro and in vivo; potent and selective β-secretase inhibitor
4000	MRK 560
	γ-secretase inhibitor; attenuates amyloid plaque deposition
5398	NQTrp
	Potent inhibitor of Aβ oligomer and fibril formation
5751	PF 3084014 hydrobromide
	Potent γ-secretase inhibitor
2408	Ro 90-7501
	Inhibitor of Aβ42 fibril formation
4426	Tanshinone IIA
	Inhibits Aβ aggregation; inhibits NF-κB and AP-1 DNA binding
6762	Urolithin A
	Inhibits amyloid-β fibrillation; also PI 3-K/Akt/mTOR signaling inhibitor