Cat. No. | Product Name / Activity |
---|---|
6363 | Avagacestat |
Highly potent γ-secretase inhibitor; orally bioavailable | |
4283 | Begacestat |
γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels | |
2870 | BMS 299897 |
γ-secretase inhibitor; reduces Aβ levels | |
4924 | CEP 1347 |
Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling | |
3360 | CGP 52411 |
Inhibits Aβ42 fibril formation. Also EGFR inhibitor | |
2442 | CGP 53353 |
Inhibitor of de novo Aβ42 assembly | |
2654 | Compound W |
γ-secretase inhibitor; reduces Aβ42 levels | |
2634 | DAPT |
γ-secretase inhibitor; reduces Aβ42 levels | |
6779 | Davunetide |
Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo | |
4524 | EGCG |
β-secretase inhibitor; inhibits formation of amyloid fibrils | |
2677 | JLK 6 |
Inhibitor of γ-secretase-mediated βAPP processing | |
2627 | L-685,458 |
Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42 | |
7081 | LY 2886721 Hydrochloride |
Inhibits Aβ1-40 and 1-42 production in vitro and in vivo; potent and selective β-secretase inhibitor | |
4000 | MRK 560 |
γ-secretase inhibitor; attenuates amyloid plaque deposition | |
5398 | NQTrp |
Potent inhibitor of Aβ oligomer and fibril formation | |
5751 | PF 3084014 hydrobromide |
Potent γ-secretase inhibitor | |
2408 | Ro 90-7501 |
Inhibitor of Aβ42 fibril formation | |
4426 | Tanshinone IIA |
Inhibits Aβ aggregation; inhibits NF-κB and AP-1 DNA binding | |
6762 | Urolithin A |
Inhibits amyloid-β fibrillation; also PI 3-K/Akt/mTOR signaling inhibitor |