Amyloid β Peptide Inhibitors
| Cat. No. | Product Name / Activity |
|---|---|
| 6363 | Avagacestat |
| Highly potent γ-secretase inhibitor; orally bioavailable | |
| 2870 | BMS 299897 |
| γ-secretase inhibitor; reduces Aβ levels | |
| 4924 | CEP 1347 |
| Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling | |
| 2442 | CGP 53353 |
| Inhibitor of de novo Aβ42 assembly | |
| 2634 | DAPT |
| γ-secretase inhibitor; reduces Aβ42 levels | |
| 6779 | Davunetide |
| Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo | |
| 4524 | EGCG |
| β-secretase inhibitor; inhibits formation of amyloid fibrils | |
| 2627 | L-685,458 |
| Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42 | |
| 7081 | LY 2886721 Hydrochloride |
| Inhibits Aβ1-40 and 1-42 production in vitro and in vivo; potent and selective β-secretase inhibitor | |
| 4000 | MRK 560 |
| γ-secretase inhibitor; attenuates amyloid plaque deposition | |
| 5751 | PF 3084014 hydrobromide |
| Potent γ-secretase inhibitor | |
| 2408 | Ro 90-7501 |
| Inhibitor of Aβ42 fibril formation | |
| 6762 | Urolithin A |
| Inhibits amyloid-β fibrillation; also PI 3-K/Akt/mTOR signaling inhibitor |
Alzheimer's Life Science Poster
Written by Dimitra Sokolova and Soyon Hong
Our Alzheimer's disease poster summarizes the genetic, molecular and cellular changes observed in the progression of this neurodegenerative disease.
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