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Cat.No. 4524 - EGCG | C22H18O11 | CAS No. 989-51-5
Description: β-secretase (BACE) inhibitor; inhibits amyloid assembly
Alternative Names: Epigallocatechin gallate
Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
Purity: ≥98% (HPLC)
Citations (5)
Reviews (3)

Biological Activity

β-secretase (BACE1) inhibitor (IC50 = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.

Technical Data

M. Wt 458.37
Formula C22H18O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 989-51-5
PubChem ID 65064
Smiles O=C(C4=CC(O)=C(O)C(O)=C4)O[C@@H]2CC1=C(O)C=C(O)C=C1O[C@@H]2[C@]3=CC(O)=C(O)C(O)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 4.58 10
DMSO 45.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 458.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.91 mL 21.82 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Jeon et al (2003) Green tea catechins as a BACE1 (β-secretase) inhibitor. Bioorg.Med.Chem.Lett. 13 3905 PMID: 14592472

Sinha et al (2012) Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem.Neurosci. 3 451 PMID: 22860214

Ahmad et al (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Ach.Biochem.Biophys. 376 338 PMID: 10775421

Shankar et al (2008) EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer. Front.Biosci. 13 440 PMID: 17981559

Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018 PMID: 16037419

Yang et al (2009) Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69 7986 PMID: 19826036

If you know of a relevant reference for EGCG, please let us know.

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Keywords: EGCG, EGCG supplier, BACE1, inhibitors, inhibits, β-secretase, b-secretase, beta-secretase, flavonoids, green, tea, antioxidants, neuroprotective, EGCG, epigallocatechin, gallate, amyloid, assembly, amyloidbeta, amyloidb, amyloidβ, glutamate, dehydrogenase, GDH, DNMT, DNA, Methyltransferas, Epigallocatechin, Amyloid, Beta, Peptides, Methyltransferases, Other, Proteases, 4524, Tocris Bioscience

5 Citations for EGCG

Citations are publications that use Tocris products. Selected citations for EGCG include:

Wei et al (2019) Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine. Nutrients 11 PMID: 31405071

Xue et al (2019) Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism. R Soc Open Sci 6 190179 PMID: 31417723

Daniels et al (2019) Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity. Sci Rep 9 2937 PMID: 30814575

Eom et al (2015) Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells. Allergy Asthma Immunol Res 48 461 PMID: 25441423

Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657

Do you know of a great paper that uses EGCG from Tocris? Please let us know.

Reviews for EGCG

Average Rating: 4.3 (Based on 3 Reviews.)

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We got expected effect on cells.
By Anonymous on 04/03/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary pancreatic ductal epithelial cells

10 μM EGCG

review image

Showed no visible purine elusions..
By Scott Scarneo on 02/06/2019
Assay Type: In Vitro
Species: Human

This was used to elute purine binding proteins from cell lysate. The drug gave no visible bands from eluted proteins examined on silver stain.

review image

By Anonymous on 05/17/2018
Species: Human

Has expected effect on cells.