Pricing Availability   Qty
Description: β-secretase (BACE) inhibitor; inhibits amyloid assembly
Alternative Names: Epigallocatechin gallate
Chemical Name: 3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
Purity: ≥98% (HPLC)
Citations (11)
Reviews (3)

Biological Activity for EGCG

EGCG is a β-secretase (BACE1) inhibitor (IC50 = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.

Technical Data for EGCG

M. Wt 458.37
Formula C22H18O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 989-51-5
PubChem ID 65064
Smiles O=C(C4=CC(O)=C(O)C(O)=C4)O[C@@H]2CC1=C(O)C=C(O)C=C1O[C@@H]2[C@]3=CC(O)=C(O)C(O)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EGCG

Solvent Max Conc. mg/mL Max Conc. mM
water 4.58 10
DMSO 45.84 100

Preparing Stock Solutions for EGCG

The following data is based on the product molecular weight 458.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.91 mL 21.82 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets for EGCG

Certificate of Analysis / Product Datasheet
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References for EGCG

References are publications that support the biological activity of the product.

Jeon et al (2003) Green tea catechins as a BACE1 (β-secretase) inhibitor. Bioorg.Med.Chem.Lett. 13 3905 PMID: 14592472

Sinha et al (2012) Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01. ACS Chem.Neurosci. 3 451 PMID: 22860214

Ahmad et al (2000) Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Ach.Biochem.Biophys. 376 338 PMID: 10775421

Shankar et al (2008) EGCG inhibits growth, invasion, angiogenesis and metastastasis of pancreatic cancer. Front.Biosci. 13 440 PMID: 17981559

Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018 PMID: 16037419

Yang et al (2009) Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69 7986 PMID: 19826036

If you know of a relevant reference for EGCG, please let us know.

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Keywords: EGCG, EGCG supplier, BACE1, inhibitors, inhibits, β-secretase, b-secretase, beta-secretase, flavonoids, green, tea, antioxidants, neuroprotective, EGCG, epigallocatechin, gallate, amyloid, assembly, amyloidbeta, amyloidb, amyloidβ, glutamate, dehydrogenase, GDH, DNMT, DNA, Methyltransferas, Epigallocatechin, Amyloid, Beta, Peptides, Methyltransferases, Other, Proteases, 4524, Tocris Bioscience

11 Citations for EGCG

Citations are publications that use Tocris products. Selected citations for EGCG include:

Warren et al (2022) Evaluation of Glutaminolysis in T Cells. Curr Protoc 2 e540 PMID: 36111948

Tomas et al (2019) The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG. Biomolecules 9 PMID: 31835741

Rainer et al (2020) The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation. Int J Mol Sci 21 PMID: 32183378

C et al (2020) The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo. Neurobiol Dis 138 104791 PMID: 32032735

Do you know of a great paper that uses EGCG from Tocris? Please let us know.

Reviews for EGCG

Average Rating: 4.3 (Based on 3 Reviews.)

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We got expected effect on cells.
By Anonymous on 04/03/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary pancreatic ductal epithelial cells

10 μM EGCG

review image

Showed no visible purine elusions..
By Scott Scarneo on 02/06/2019
Assay Type: In Vitro
Species: Human

This was used to elute purine binding proteins from cell lysate. The drug gave no visible bands from eluted proteins examined on silver stain.

review image

By Anonymous on 05/17/2018
Species: Human

Has expected effect on cells.