A 419259 trihydrochloride

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Description: Inhibitor of Src family kinases
Chemical Name: 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
Purity: ≥98% (HPLC)
Citations (6)
Reviews (1)

Biological Activity for A 419259 trihydrochloride

A 419259 trihydrochloride is a potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.

Compound Libraries for A 419259 trihydrochloride

A 419259 trihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for A 419259 trihydrochloride

M. Wt 592.01
Formula C29H34N6O.3HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1435934-25-0
PubChem ID 76848881
Smiles NC1=C2C(N([C@H]5CC[C@H](N6CCN(C)CC6)CC5)C=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 419259 trihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 59.2 100
DMSO 11.84 20

Preparing Stock Solutions for A 419259 trihydrochloride

The following data is based on the product molecular weight 592.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.69 mL 8.45 mL 16.89 mL
5 mM 0.34 mL 1.69 mL 3.38 mL
10 mM 0.17 mL 0.84 mL 1.69 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for A 419259 trihydrochloride

Certificate of Analysis / Product Datasheet
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References for A 419259 trihydrochloride

References are publications that support the biological activity of the product.

Wilson et al (2002) Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 21 8075 PMID: 12444544

Pene-Dumitrescu et al (2008) An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad spectrum Src family kinase inhibitor A-419259. Oncogene 27 7055 PMID: 18794796

Saito et al (2013) A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci.Transl.Med. 5 PMID: 23596204

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Keywords: A 419259 trihydrochloride, A 419259 trihydrochloride supplier, A419259, Src, family, kinase, SFK, inhibitors, inhibits, apoptosis, inducers, trihydrochloride, 3HCl, Kinases, 3914, Tocris Bioscience

6 Citations for A 419259 trihydrochloride

Citations are publications that use Tocris products. Selected citations for A 419259 trihydrochloride include:

Alessandra et al (2023) Recapitulating porcine cardiac development in vitro: from expanded potential stem cell to embryo culture models. Front Cell Dev Biol 11 1111684 PMID: 37261075

Juan Carlos et al (2021) Protocol for the generation of blastocyst-like structures from mouse extended pluripotent stem cells. STAR Protoc 2 100745 PMID: 34430918

Li et al (2019) Generation of blastocyst-like structures from mouse embryonic and adult cell cultures. Cell 179 687 PMID: 31626770

Gao et al (2019) Establishment of porcine and human expanded potential stem cells. Nat Cell Bio 21 687 PMID: 31160711

Do you know of a great paper that uses A 419259 trihydrochloride from Tocris? Please let us know.

Reviews for A 419259 trihydrochloride

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Generation of EPS-blastoids.
By Anonymous on 02/27/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: EPS


PMID: 31626770
review image