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KB SRC 4
Potent and selective c-Src inhibitor (Ki = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (Kd values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 555.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||9.01 mL||45.04 mL||90.09 mL|
|1 mM||1.8 mL||9.01 mL||18.02 mL|
|2 mM||0.9 mL||4.5 mL||9.01 mL|
|10 mM||0.18 mL||0.9 mL||1.8 mL|
References are publications that support the biological activity of the product.
Brandvold et al (2012) Development of a highly selective c-Src kinase inhibitor. ACS Chem.Biol. 7 1393 PMID: 22594480
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Keywords: KB SRC 4, KB SRC 4 supplier, KBSRC4, c-Src, Src, kinases, inhibitors, inhibits, 4T1, mammary, carcinoma, tumor, cells, breast, cancer, non-receptor, tyrosine, Kinases, 4660, Tocris Bioscience
2 Citations for KB SRC 4
Citations are publications that use Tocris products. Selected citations for KB SRC 4 include:
Carmona et al (2016) Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Oncogene 35 5155 PMID: 26996666
Kim et al (2014) An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol 34 4368 PMID: 25312644
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