KB SRC 4

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Cat.No. 4660 - KB SRC 4 | C32H23ClN8 | CAS No. 1380088-03-8
Description: Potent and selective c-Src inhibitor
Chemical Name: 1-[3-[1-([1,1'-Biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective c-Src inhibitor (Ki = 44 nM); does not inhibit c-Abl at concentrations up to 125 μM. Selective between Src family members (Kd values are 86, 160, 240, 720, 3200, 4400, and >40,000 nM for c-Src, Lck, Fgr, Yes, Lyn, Hck and Fyn respectively). Significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells.

Compound Libraries

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Technical Data

M. Wt 555.03
Formula C32H23ClN8
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1380088-03-8
PubChem ID 73349077
InChI Key UHIZYQVRKSWIFO-UHFFFAOYSA-N
Smiles NC1=C2C(N(C4=CC=CC(C5=CN=NN5CC6=CC(C7=CC=CC=C7)=CC=C6)=C4)N=C2C3=CC=C(Cl)C=C3)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.1 20

Preparing Stock Solutions

The following data is based on the product molecular weight 555.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.8 mL 9.01 mL 18.02 mL
5 mM 0.36 mL 1.8 mL 3.6 mL
10 mM 0.18 mL 0.9 mL 1.8 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Brandvold et al (2012) Development of a highly selective c-Src kinase inhibitor. ACS Chem.Biol. 7 1393 PMID: 22594480


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Keywords: KB SRC 4, supplier, KBSRC4, c-Src, Src, kinases, inhibitors, inhibits, 4T1, mammary, carcinoma, tumor, cells, breast, cancer, non-receptor, tyrosine, kinases, Src, Kinases, Src, Kinases, Tocris Bioscience

1 Citation for KB SRC 4

Citations are publications that use Tocris products. Selected citations for KB SRC 4 include:

Kim et al (2014) An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol 34 4368 PMID: 25312644


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