Potent inhibitor of lymphocyte specific kinase (Lck). IC50 values are 0.007, 0.021, 0.042 and 0.20 μM for Lck, Lyn, Src and Syk kinases respectively. Displays >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Inhibits T cell proliferation in vitro and inhibits arthritis in two in vivo models. Orally active.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||5.31||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 530.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.88 mL||9.42 mL||18.85 mL|
|5 mM||0.38 mL||1.88 mL||3.77 mL|
|10 mM||0.19 mL||0.94 mL||1.88 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References are publications that support the biological activity of the product.
Martin et al (2008) Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory J.Med.Chem. 51 1637 PMID: 18278858
If you know of a relevant reference for TC-S 7003, please let us know.
View Related Products by Product Action
Keywords: TC-S 7003, TC-S 7003 supplier, Lck, kinases, inhibitors, inhibits, lymphocyte, specific, Src, Kinases, 3567, Tocris Bioscience
Citations for TC-S 7003
Citations are publications that use Tocris products.
Currently there are no citations for TC-S 7003. Do you know of a great paper that uses TC-S 7003 from Tocris? Please let us know.
Reviews for TC-S 7003
There are currently no reviews for this product. Be the first to review TC-S 7003 and earn rewards!
Have you used TC-S 7003?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.