LCB 03-0110 dihydrochloride

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Cat.No. 5592 - LCB 03-0110 dihydrochloride | C24H23N3O2S.2HCl
Description: Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.

Technical Data

M. Wt 490.45
Formula C24H23N3O2S.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 121513872
InChI Key OEWGAUGZPPUIPF-UHFFFAOYSA-N
Smiles OC1=CC=CC(NC2=CC=NC3=C2SC(C4=CC=CC(CN5CCOCC5)=C4)=C3)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.05 100
water 49.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 490.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.19 mL 20.39 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sun et al (2012) LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J.Pharmacol.Exp.Ther. 340 510 PMID: 22128347


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View all Src Kinase Inhibitors

Keywords: src kinase inhibitors inhibits potent discoidin domain receptor DDR wound healing Bruton's tyrosine BTK syk anti-inflammatory potent Src Kinases

Citations for LCB 03-0110 dihydrochloride

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Literature in this Area

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Pathways for LCB 03-0110 dihydrochloride

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