Tilfrinib

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Cat.No. 5579 - Tilfrinib | C17H13N3O | CAS No. 1600515-49-8
Description: Potent and selective breast tumor kinase (Brk) inhibitor
Chemical Name: 3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.

Licensing Information

Sold under license from Martin-Luther-Universität-Halle-Wittenburg

Technical Data

M. Wt 275.3
Formula C17H13N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1600515-49-8
PubChem ID 76332983
InChI Key RXPZOSHFGJWSLQ-UHFFFAOYSA-N
Smiles OC1=CC=CC(NC2=C3C(NC4=CC=CC=C43)=NC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 275.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mahmoud et al (2014) Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg.Med.Chem.Lett. 24 1948 PMID: 24650640


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Keywords: potent selective breast tumor kinases Brk antiproliferative cancer tyrosine-protein kinases 6 TK6 inhibitors inhibits Src Kinases

Citations for Tilfrinib

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Literature in this Area

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • Receptor Serine/Threonine Kinases

Pathways for Tilfrinib

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