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Description: Potent and selective breast tumor kinase (Brk) inhibitor
Chemical Name: 3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
Purity: ≥98% (HPLC)

Biological Activity for Tilfrinib

Tilfrinib is a potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.

Licensing Information

Sold under license from Martin-Luther-Universität-Halle-Wittenburg

Compound Libraries for Tilfrinib

Tilfrinib is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Tilfrinib

M. Wt 275.3
Formula C17H13N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1600515-49-8
PubChem ID 76332983
Smiles OC1=CC=CC(NC2=C3C(NC4=CC=CC=C43)=NC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tilfrinib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.53 100

Preparing Stock Solutions for Tilfrinib

The following data is based on the product molecular weight 275.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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References for Tilfrinib

References are publications that support the biological activity of the product.

Mahmoud et al (2014) Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg.Med.Chem.Lett. 24 1948 PMID: 24650640

If you know of a relevant reference for Tilfrinib, please let us know.

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Citations for Tilfrinib

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