Potent and selective breast tumor kinase (Brk, also known as tyrosine-protein kinase 6, PTK6) inhibitor (IC50 = 3.15 nM). Exhibits >1000-fold selectivity for Brk over a panel of other kinases. Inhibits proliferation of breast cancer cells in vitro.
Sold under license from Martin-Luther-Universität-Halle-Wittenburg
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 275.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.63 mL||18.16 mL||36.32 mL|
|5 mM||0.73 mL||3.63 mL||7.26 mL|
|10 mM||0.36 mL||1.82 mL||3.63 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References are publications that support the biological activity of the product.
Mahmoud et al (2014) Discovery of 4-anilino α-carbolines as novel Brk inhibitors. Bioorg.Med.Chem.Lett. 24 1948 PMID: 24650640
If you know of a relevant reference for Tilfrinib, please let us know.
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Keywords: Tilfrinib, Tilfrinib supplier, potent, selective, breast, tumor, kinases, Brk, antiproliferative, cancer, tyrosine-protein, 6, TK6, inhibitors, inhibits, Src, Kinases, 5579, Tocris Bioscience
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