You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Saracatinib
Saracatinib is a potent and selective Src tyrosine kinase family inhibitor (IC50 = 4-10 nM). Inhibits Src, c-Yes, Fyn, Lyn, Blk, Fgr, and Lck. Exhibits selectivity over other tyrosine kinases (IC50 values are 30, 66 and 200 nM for v-Abl, EGFR and c-Kit, respectively). Suppresses invasion of HT1080 cells through a collagen matrix and inhibits metastasis in a murine model of bladder cancer. Inhibits the growth of prostate cancer cell lines. Also suppresses MERS-CoV replication at the early stage of replication (EC50 = 2.9 μM) and displays broad-spectrum activity against other human coronaviruses. Also blocks dengue virus RNA replication. Reverses memory deficit in a mouse AD model and rescues synapse density. Inhibits osteoclast activity, resorption and formation. Induces autophagy. Orally bioavailable.
Compound Libraries for Saracatinib
Technical Data for Saracatinib
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Saracatinib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Saracatinib
The following data is based on the product molecular weight 542.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.84 mL||9.22 mL||18.45 mL|
|5 mM||0.37 mL||1.84 mL||3.69 mL|
|10 mM||0.18 mL||0.92 mL||1.84 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References for Saracatinib
References are publications that support the biological activity of the product.
Hennequin et al (2006) N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J.Med.Chem. 49 6465 PMID: 17064066
Green et al (2009) Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530. Mol.Oncol. 3 248 PMID: 19393585
De Wispelaere et al (2013) The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J.Virol. 87 7367 PMID: 23616652
Kaufman et al (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann.Neurol. 77 953 PMID: 25707991
If you know of a relevant reference for Saracatinib, please let us know.
View Related Products by Product Action
Keywords: Saracatinib, Saracatinib supplier, AZD0530, AZD_0530, potent, selective, Src, tyrosine, kinase, family, inhibitors, inhibits, c-Yes, Fyn, Lyn, Blk, Fgr, Lck, MERS-cov, Covid-19, antiviral, dengue, viruses, AD, Alzheimers, disease, osteoclast, activity, AZD, 0530, Kinases, COVID-19, Coronavirus, 7189, Tocris Bioscience
Citations for Saracatinib
Citations are publications that use Tocris products.
Currently there are no citations for Saracatinib. Do you know of a great paper that uses Saracatinib from Tocris? Please let us know.
Reviews for Saracatinib
There are currently no reviews for this product. Be the first to review Saracatinib and earn rewards!
Have you used Saracatinib?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.