MLR 1023

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Cat.No. 4582 - MLR 1023 | C11H10N2O2 | CAS No. 41964-07-2
Description: Selective allosteric activator of Lyn kinase
Chemical Name: 5-(3-Methylphenoxy)-2(1H)-pyrimidinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective allosteric activator of Lyn kinase (EC50 = 63 nM); displays no significant activity against a range of 47 other kinases, including other Src family kinases such as Fyn, Lck and Src kinase. Reduces blood glucose levels without affecting in vivo insulin secretion. Orally bioavailable.

Compound Libraries

MLR 1023 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 202.21
Formula C11H10N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 41964-07-2
PubChem ID 39065
InChI Key HJQILFPVRNHTIG-UHFFFAOYSA-N
Smiles CC1=CC(OC2=CNC(N=C2)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.22 100
ethanol 4.04 20

Preparing Stock Solutions

The following data is based on the product molecular weight 202.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.95 mL 24.73 mL 49.45 mL
5 mM 0.99 mL 4.95 mL 9.89 mL
10 mM 0.49 mL 2.47 mL 4.95 mL
50 mM 0.1 mL 0.49 mL 0.99 mL

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References

References are publications that support the biological activity of the product.

Ochman et al (2012) The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J.Pharmacol.Exp.Ther. 342 23 PMID: 22431203

Saporito et al (2012) MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J.Pharmacol.Exp.Ther. 342 15 PMID: 22473614


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