MLR 1023

Pricing Availability   Qty
Description: Selective allosteric activator of Lyn kinase
Chemical Name: 5-(3-Methylphenoxy)-2(1H)-pyrimidinone
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity for MLR 1023

MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM); displays no significant activity against a range of 47 other kinases, including other Src family kinases such as Fyn, Lck and Src kinase. Reduces blood glucose levels without affecting in vivo insulin secretion. Orally bioavailable.

Compound Libraries for MLR 1023

MLR 1023 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for MLR 1023

M. Wt 202.21
Formula C11H10N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 41964-07-2
PubChem ID 39065
InChI Key HJQILFPVRNHTIG-UHFFFAOYSA-N
Smiles CC1=CC(OC2=CNC(N=C2)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MLR 1023

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.22 100
ethanol 4.04 20

Preparing Stock Solutions for MLR 1023

The following data is based on the product molecular weight 202.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.95 mL 24.73 mL 49.45 mL
5 mM 0.99 mL 4.95 mL 9.89 mL
10 mM 0.49 mL 2.47 mL 4.95 mL
50 mM 0.1 mL 0.49 mL 0.99 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for MLR 1023

References are publications that support the biological activity of the product.

Ochman et al (2012) The Lyn kinase activator MLR-1023 is a novel Ins receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J.Pharmacol.Exp.Ther. 342 23 PMID: 22431203

Saporito et al (2012) MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J.Pharmacol.Exp.Ther. 342 15 PMID: 22473614


If you know of a relevant reference for MLR 1023, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Src Kinase Activators

Keywords: MLR 1023, MLR 1023 supplier, MLR1023, type, II, diabetes, antidiabetic, hyperglycemia, lyn, kinase, inhibitors, inhibits, selective, Src, Kinases, 4582, Tocris Bioscience

1 Citation for MLR 1023

Citations are publications that use Tocris products. Selected citations for MLR 1023 include:

Iida et al (2019) Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy. Nat Commun 10 4262 PMID: 31537808


Do you know of a great paper that uses MLR 1023 from Tocris? Please let us know.

Reviews for MLR 1023

There are currently no reviews for this product. Be the first to review MLR 1023 and earn rewards!

Have you used MLR 1023?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases