You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
TL 0259 New
Selective and highly potent Fgr and Lyn inhibitor (IC50 values are 0.03 and 0.1 nM, respectively). Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases. Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro. Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts. Orally bioavailable.
Sold under license from Dana-Farber Cancer Institute
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 682.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||2.93 mL||14.65 mL||29.3 mL|
|2.5 mM||0.59 mL||2.93 mL||5.86 mL|
|5 mM||0.29 mL||1.47 mL||2.93 mL|
|25 mM||0.06 mL||0.29 mL||0.59 mL|
References are publications that support the biological activity of the product.
Weir et al (2018) Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo. ACS Chem.Biol. 13 1551 PMID: 29763550
If you know of a relevant reference for TL 0259, please let us know.
View Related Products by Product Action
Keywords: TL 0259, TL 0259 supplier, TL0259, Fgr, Lyn, Src, family, nonreceptor, tyrosine, kinases, inhibitors, inhibits, potent, selective, orally, bioavailable, Kinases, 6981, Tocris Bioscience
Citations for TL 0259
Citations are publications that use Tocris products.
Currently there are no citations for TL 0259. Do you know of a great paper that uses TL 0259 from Tocris? Please let us know.
Reviews for TL 0259
There are currently no reviews for this product. Be the first to review TL 0259 and earn rewards!
Have you used TL 0259?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.