Squarunkin A hydrochloride

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Description: UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation
Chemical Name: Ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)amino)cyclobut-1-en-1-yl)amino)piperidine-1-carboxylate hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for Squarunkin A hydrochloride

Squarunkin A hydrochloride is a potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.

Compound Libraries for Squarunkin A hydrochloride

Squarunkin A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Squarunkin A hydrochloride

M. Wt 560.01
Formula C25H32F3N5O4.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2253744-55-5
Smiles CCOC(N1CCC(NC2=C(C(C2=O)=O)NCCN3CCN(C4=CC(C(F)(F)F)=CC=C4)CC3)CC1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Squarunkin A hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28 50

Preparing Stock Solutions for Squarunkin A hydrochloride

The following data is based on the product molecular weight 560.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.57 mL 17.86 mL 35.71 mL
2.5 mM 0.71 mL 3.57 mL 7.14 mL
5 mM 0.36 mL 1.79 mL 3.57 mL
25 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets for Squarunkin A hydrochloride

Certificate of Analysis / Product Datasheet
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References for Squarunkin A hydrochloride

References are publications that support the biological activity of the product.

Mejuch et al (2017) Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 56 6181 PMID: 28471079

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Citations for Squarunkin A hydrochloride

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