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Squarunkin A hydrochloride is a potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.
Squarunkin A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 560.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.57 mL||17.86 mL||35.71 mL|
|2.5 mM||0.71 mL||3.57 mL||7.14 mL|
|5 mM||0.36 mL||1.79 mL||3.57 mL|
|25 mM||0.07 mL||0.36 mL||0.71 mL|
References are publications that support the biological activity of the product.
Mejuch et al (2017) Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 56 6181 PMID: 28471079
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Keywords: Squarunkin A hydrochloride, Squarunkin A hydrochloride supplier, Squarunkin, A, HCl, protein, interaction, inhibitor, inhibits, chaperone, cargo, UNC199, myristoylated, src, 2101958-02-3, Src, Kinases, 6364, Tocris Bioscience
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