PD 166285 dihydrochloride

Pricing Availability   Qty
Description: Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
Chemical Name: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for PD 166285 dihydrochloride

PD 166285 dihydrochloride is a potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PD 166285 dihydrochloride

PD 166285 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PD 166285 dihydrochloride

M. Wt 585.35
Formula C26H27Cl2N5O2.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 212391-63-4
PubChem ID 9916391
Smiles CN(C1=NC(NC4=CC=C(OCCN(CC)CC)C=C4)=NC=C1C=C2C3=C(Cl)C=CC=C3Cl)C2=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PD 166285 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 58.53 100

Preparing Stock Solutions for PD 166285 dihydrochloride

The following data is based on the product molecular weight 585.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.71 mL 8.54 mL 17.08 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
10 mM 0.17 mL 0.85 mL 1.71 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for PD 166285 dihydrochloride

References for PD 166285 dihydrochloride

References are publications that support the biological activity of the product.

Panek et al (1997) In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J.Pharmacol.Exp.Ther. 283 1433 PMID: 9400019

Wang et al (2001) Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator. Cancer Res. 61 8211 PMID: 11719452

Hashimoto et al (2006) Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 6 292 PMID: 17177986

If you know of a relevant reference for PD 166285 dihydrochloride, please let us know.

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2 Citations for PD 166285 dihydrochloride

Citations are publications that use Tocris products. Selected citations for PD 166285 dihydrochloride include:

Hui et al (2021) Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice. Front Cell Dev Biol 9 687522 PMID: 34124073

Gaffré et al (2011) A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes. Toxicol Lett 138 3735 PMID: 21795279

Do you know of a great paper that uses PD 166285 dihydrochloride from Tocris? Please let us know.

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