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PD 166285 dihydrochloride
Biological Activity for PD 166285 dihydrochloride
PD 166285 dihydrochloride is a potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for PD 166285 dihydrochloride
Technical Data for PD 166285 dihydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PD 166285 dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PD 166285 dihydrochloride
The following data is based on the product molecular weight 585.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.71 mL||8.54 mL||17.08 mL|
|5 mM||0.34 mL||1.71 mL||3.42 mL|
|10 mM||0.17 mL||0.85 mL||1.71 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
Product Datasheets for PD 166285 dihydrochloride
References for PD 166285 dihydrochloride
References are publications that support the biological activity of the product.
Panek et al (1997) In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J.Pharmacol.Exp.Ther. 283 1433 PMID: 9400019
Wang et al (2001) Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator. Cancer Res. 61 8211 PMID: 11719452
Hashimoto et al (2006) Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 6 292 PMID: 17177986
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Keywords: PD 166285 dihydrochloride, PD 166285 dihydrochloride supplier, Src, FGFR, PDGFRbeta, PDGFRb, PDGFRβ, PDGFR, Wee1, inhibitors, inhibits, Pfizer, RTKs, receptor, tyrosine, kinases, fibroblast, platelet, growth, factors, PD166285, Kinases, Checkpoint, Control, 3785, Tocris Bioscience
1 Citation for PD 166285 dihydrochloride
Citations are publications that use Tocris products. Selected citations for PD 166285 dihydrochloride include:
Gaffré et al (2011) A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes. Toxicol Lett 138 3735 PMID: 21795279
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Literature in this Area
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