1-Naphthyl PP1

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Cat.No. 3063 - 1-Naphthyl PP1 | C19H19N5 | CAS No. 221243-82-9
Description: Src family kinase inhibitor; also inhibits c-Abl
Alternative Names: 1-NA-PP 1
Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Compound Libraries

1-Naphthyl PP1 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 317.39
Formula C19H19N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 221243-82-9
PubChem ID 4877
InChI Key XSHQBIXMLULFEV-UHFFFAOYSA-N
Smiles NC1=NC=NC2=C1C(C3=C4C(C=CC=C4)=CC=C3)=NN2C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.35 20

Preparing Stock Solutions

The following data is based on the product molecular weight 317.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.75 mL 31.51 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395 PMID: 11014197

Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627 PMID:


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Keywords: 1-Naphthyl PP1, supplier, Src, family, kinase, inhibits, inhibitors, c-Abl, v-Src, c-Fyn, 1-NaphthylPP1, 1NAPP1, 1-NA-PP, 1, Src, Kinases, Abl, Kinase, Src, Kinases, Tocris Bioscience

4 Citations for 1-Naphthyl PP1

Citations are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

Kim et al (2013) Dual mechanisms prevent premature chromosome segregation during meiosis. Cell Death Dis 27 2139 PMID: 24115770

Lo and Hollingsworth (2011) Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1. Methods Mol Biol 745 135 PMID: 21660693

Chen et al (2015) Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol 13 e1002329 PMID: 26682552

Meyer et al (2015) Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae. Genes Dev 26 2986 PMID: 26157162


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