1-Naphthyl PP1

Pricing Availability   Qty
Description: Src family kinase inhibitor; also inhibits c-Abl
Alternative Names: 1-NA-PP 1
Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥99% (HPLC)
Citations (6)

Biological Activity for 1-Naphthyl PP1

1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Compound Libraries for 1-Naphthyl PP1

1-Naphthyl PP1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for 1-Naphthyl PP1

M. Wt 317.39
Formula C19H19N5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 221243-82-9
PubChem ID 4877
Smiles NC1=NC=NC2=C1C(C3=C4C(C=CC=C4)=CC=C3)=NN2C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1-Naphthyl PP1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.35 20

Preparing Stock Solutions for 1-Naphthyl PP1

The following data is based on the product molecular weight 317.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.75 mL 78.77 mL 157.53 mL
1 mM 3.15 mL 15.75 mL 31.51 mL
2 mM 1.58 mL 7.88 mL 15.75 mL
10 mM 0.32 mL 1.58 mL 3.15 mL

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Product Datasheets for 1-Naphthyl PP1

Certificate of Analysis / Product Datasheet
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References for 1-Naphthyl PP1

References are publications that support the biological activity of the product.

Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395 PMID: 11014197

Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627

If you know of a relevant reference for 1-Naphthyl PP1, please let us know.

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6 Citations for 1-Naphthyl PP1

Citations are publications that use Tocris products. Selected citations for 1-Naphthyl PP1 include:

Chen et al (2015) Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis. PLoS Biol 13 e1002329 PMID: 26682552

O'Neill et al (2016) Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol 215 217 PMID: 27810913

Lo and Hollingsworth (2011) Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1. Methods Mol Biol 745 135 PMID: 21660693

Meyer et al (2015) Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae. Genes Dev 26 2986 PMID: 26157162

Do you know of a great paper that uses 1-Naphthyl PP1 from Tocris? Please let us know.

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