PP 3

Pricing Availability Delivery Time Qty
Cat.No. 2794 - PP 3 | C11H9N5 | CAS No. 5334-30-5
Description: Negative control for PP 2 (Cat. No. 1407)
Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Negative control for the Src kinase inhibitor PP 2 (Cat. No. 1407). Inhibits EGFR kinase (IC50 = 2.7 μM).

Technical Data

M. Wt 211.22
Formula C11H9N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 5334-30-5
PubChem ID 4879
InChI Key KKDPIZPUTYIBFX-UHFFFAOYSA-N
Smiles NC1=NC=NC2=C1C=NN2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.12 100
ethanol 5.28 25

Preparing Stock Solutions

The following data is based on the product molecular weight 211.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.73 mL 23.67 mL 47.34 mL
5 mM 0.95 mL 4.73 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.73 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Traxler et al (1997) Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 40 3601 PMID: 9357527

Hou et al (2007) PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 420 235 PMID:


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View all Src Kinase Inhibitors

Keywords: Negative control PP 2 EGFR-kinases inhibitors inhibits Src negative Epidermal Growth Factors Receptors ErbB Her EGFR Receptor Tyrosine RTKs PP3 Src Kinases

4 Citations for PP 3

Citations are publications that use Tocris products. Selected citations for PP 3 include:

Vijayakumar et al (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Neural Regen Res 128 251 PMID: 25413351

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481

Rosas et al (2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Cell 9 2164 PMID: 25657738

Kupferman et al (2014) Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. J Neuroimmune Pharmacol 158 1335 PMID: 25201528


Do you know of a great paper that uses PP 3 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

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Cancer Research Product Guide

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A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for PP 3

Protocols

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