PP 3

Pricing Availability   Qty
Cat.No. 2794 - PP 3 | C11H9N5 | CAS No. 5334-30-5
Description: Negative control for PP 2 (Cat. No. 1407)
Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews
Literature

Biological Activity

Negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC50 = 2.7 μM).

Active Analog also available.

Technical Data

M. Wt 211.22
Formula C11H9N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 5334-30-5
PubChem ID 4879
InChI Key KKDPIZPUTYIBFX-UHFFFAOYSA-N
Smiles NC1=NC=NC2=C1C=NN2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.12 100
ethanol 5.28 25

Preparing Stock Solutions

The following data is based on the product molecular weight 211.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.73 mL 23.67 mL 47.34 mL
5 mM 0.95 mL 4.73 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.73 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Traxler et al (1997) Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 40 3601 PMID: 9357527

Hou et al (2007) PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 420 235


If you know of a relevant reference for PP 3, please let us know.

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Keywords: PP 3, PP 3 supplier, Negative, control, PP, 2, EGFR-kinases, inhibitors, inhibits, Src, negative, Epidermal, Growth, Factors, Receptors, ErbB, Her, EGFR, Receptor, Tyrosine, RTKs, PP3, Kinases, 2794, Tocris Bioscience

7 Citations for PP 3

Citations are publications that use Tocris products. Selected citations for PP 3 include:

Rosas et al (2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Cell 9 2164 PMID: 25657738

Kupferman et al (2014) Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. J Neuroimmune Pharmacol 158 1335 PMID: 25201528

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481

Hass et al (2017) Mathematical model of early Reelin-induced Src family kinase-mediated signaling. PLoS One 12 e0186927 PMID: 29049379

Vijayakumar et al (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Neural Regen Res 128 251 PMID: 25413351

Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998

Li et al (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest 126 389 PMID: 26657863


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Literature in this Area

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