Negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC50 = 2.7 μM).
Active Analog also available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 211.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.73 mL||23.67 mL||47.34 mL|
|5 mM||0.95 mL||4.73 mL||9.47 mL|
|10 mM||0.47 mL||2.37 mL||4.73 mL|
|50 mM||0.09 mL||0.47 mL||0.95 mL|
References are publications that support the biological activity of the product.
Traxler et al (1997) Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 40 3601 PMID: 9357527
Hou et al (2007) PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 420 235
If you know of a relevant reference for PP 3, please let us know.
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7 Citations for PP 3
Citations are publications that use Tocris products. Selected citations for PP 3 include:
Rosas et al (2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Cell 9 2164 PMID: 25657738
Kupferman et al (2014) Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. J Neuroimmune Pharmacol 158 1335 PMID: 25201528
Hass et al (2017) Mathematical model of early Reelin-induced Src family kinase-mediated signaling. PLoS One 12 e0186927 PMID: 29049379
Vijayakumar et al (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. Neural Regen Res 128 251 PMID: 25413351
Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481
Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998
Li et al (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest 126 389 PMID: 26657863
Do you know of a great paper that uses PP 3 from Tocris? Please let us know.
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Literature in this Area
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