SU 6656

Pricing Availability   Qty
Cat.No. 6475 - SU 6656 | C19H21N3O3S | CAS No. 330161-87-0
Description: Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable
Chemical Name: 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent ATP-competitive Src family kinase inhibitor (IC50 values are 0.02, 0.13, 0.17, 0.28 and 6.88 nM for Yes, Lyn, Fyn, Src and Lck, respectively). Exhibits > 6.5 fold selectivity for Src family over other kinases. Also AMPK inhibitor (IC50 = 0.22 μM for the α2 kinase domain). Cell permeable.

Technical Data

M. Wt 371.45
Formula C19H21N3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 330161-87-0
PubChem ID 5312137
InChI Key LOGJQOUIVKBFGH-YBEGLDIGSA-N
Smiles CN(S(=O)(C1=CC=C2NC(/C(C2=C1)=C\C3=CC4=C(N3)CCCC4)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 371.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Ross et al (2017) Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sorafenib. Cell.Chem.Biol. 24 813 PMID: 28625738

Blake et al (2000) SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol.Cell Biol. 20 9018 PMID: 11074000


If you know of a relevant reference for SU 6656, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Src Kinase Inhibitors

Keywords: SU 6656, SU 6656 supplier, SU6656, potent, Src, family, kinases, inhibitors, inhibits, Lck, Yes, Lyn, Fyn, AMPK, Kinases, 6475, Tocris Bioscience

Citations for SU 6656

Citations are publications that use Tocris products.

Currently there are no citations for SU 6656. Do you know of a great paper that uses SU 6656 from Tocris? Please let us know.

Reviews for SU 6656

There are currently no reviews for this product. Be the first to review SU 6656 and earn rewards!

Have you used SU 6656?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases