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Biological Activity for SU 6656
SU 6656 is a potent ATP-competitive Src family kinase inhibitor (IC50 values are 0.02, 0.13, 0.17, 0.28 and 6.88 nM for Yes, Lyn, Fyn, Src and Lck, respectively). Exhibits > 6.5 fold selectivity for Src family over other kinases. Also AMPK inhibitor (IC50 = 0.22 μM for the α2 kinase domain). Cell permeable.
Technical Data for SU 6656
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SU 6656
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SU 6656
The following data is based on the product molecular weight 371.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.69 mL||13.46 mL||26.92 mL|
|5 mM||0.54 mL||2.69 mL||5.38 mL|
|10 mM||0.27 mL||1.35 mL||2.69 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for SU 6656
References are publications that support the biological activity of the product.
Ross et al (2017) Mechanisms of paradoxical activation of AMPK by the kinase inhibitors SU6656 and sora. Cell.Chem.Biol. 24 813 PMID: 28625738
Blake et al (2000) SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol.Cell Biol. 20 9018 PMID: 11074000
If you know of a relevant reference for SU 6656, please let us know.
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Keywords: SU 6656, SU 6656 supplier, SU6656, potent, Src, family, kinases, inhibitors, inhibits, Lck, Yes, Lyn, Fyn, AMPK, Kinases, 6475, Tocris Bioscience
1 Citation for SU 6656
Citations are publications that use Tocris products. Selected citations for SU 6656 include:
Andrii et al (2020) GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons. Mov Disord 35 2279-2289 PMID: 32964492
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Literature in this Area
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