Abl Kinase

The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2) subtypes. c-Abl is localized at many subcellular sites including the nucleus, cytoplasm, mitochondria and endoplasmic reticulum, where it interacts with several proteins.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3716 Adaphostin
p210bcr/abl kinase inhibitor
4274 AP 24534
Potent multi-kinase and pan-Bcr-Abl inhibitor
4361 Bosutinib
Dual Src-Abl inhibitor; antiproliferative
4399 GNF 2
Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
4908 GNF 5
Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
5906 Imatinib mesylate
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
3063 1-Naphthyl PP1
Inhibitor of c-Abl, v-Src and c-Fyn
4965 PD 180970
p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT
4730 PPY A
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Related Targets

    The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2) subtypes. c-Abl is localized at several subcellular sites including the nucleus, cytoplasm, mitochondria and endoplasmic reticulum, where it interacts with a large variety of cellular proteins including signaling adaptors, kinases, phosphatases, cell cycle regulators, transcription factors and cytoskeletal proteins.

    Due to its diverse range of targets, c-Abl has been implicated in many cellular processes including regulation of cell growth and survival, oxidative stress and DNA-damage responses, and actin dynamics and cell migration. The Abl family have significant structural homology to the Src tyrosine kinase family, but have a unique long carboxy-terminal extension that contains protein-protein interaction sites and acts as the binding site for targets such as ATM, p53 and pRb. c-Abl is medically important as there is a causal link between the Abl-Bcr fusion protein (caused by a t(9,22) translocation) and development of chronic myeloid leukemia.

    Literature for Abl Kinase

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases

    Abl Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Abl Human ABL1 NM_007313 P00519
    Mouse Abl1 NM_001112703 P00520
    Rat Abl1 XM_231137 Q2PYT3
    Arg Human ABL2 NM_005158 P42684
    Mouse Abl2 NM_009595 Q4JIM5
    Rat Abl2 NM_001107186 XP_222768