Abl Kinase

The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2) subtypes. c-Abl is localized at many subcellular sites including the nucleus, cytoplasm, mitochondria and endoplasmic reticulum, where it interacts with several proteins.

Products
Background
Gene Data

Inhibitors

Cat No Product Name / Activity
3716 Adaphostin
p210bcr/abl kinase inhibitor
4274 AP 24534
Potent multi-kinase and pan-Bcr-Abl inhibitor
4361 Bosutinib
Dual Src-Abl inhibitor; antiproliferative
4399 GNF 2
Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
4908 GNF 5
Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
5906 Imatinib mesylate
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
3063 1-Naphthyl PP1
Inhibitor of c-Abl, v-Src and c-Fyn
4965 PD 180970
p210Bcr/Abl kinase inhibitor; also inhibits c-Src and KIT
4730 PPY A
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2) subtypes. c-Abl is localized at several subcellular sites including the nucleus, cytoplasm, mitochondria and endoplasmic reticulum, where it interacts with a large variety of cellular proteins including signaling adaptors, kinases, phosphatases, cell cycle regulators, transcription factors and cytoskeletal proteins.

Due to its diverse range of targets, c-Abl has been implicated in many cellular processes including regulation of cell growth and survival, oxidative stress and DNA-damage responses, and actin dynamics and cell migration. The Abl family have significant structural homology to the Src tyrosine kinase family, but have a unique long carboxy-terminal extension that contains protein-protein interaction sites and acts as the binding site for targets such as ATM, p53 and pRb. c-Abl is medically important as there is a causal link between the Abl-Bcr fusion protein (caused by a t(9,22) translocation) and development of chronic myeloid leukemia.

Abl Kinase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Abl Human ABL1 NM_007313 P00519
Mouse Abl1 NM_001112703 P00520
Rat Abl1 XM_231137 Q2PYT3
Arg Human ABL2 NM_005158 P42684
Mouse Abl2 NM_009595 Q4JIM5
Rat Abl2 NM_001107186 XP_222768