GIT 27

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Cat.No. 3270 - GIT 27 | C11H11NO3 | CAS No. 6501-72-0
Description: Immunomodulator; reduces production of pro-inflammatory cytokines
Chemical Name: 4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Orally active immunomodulatory agent that primarily targets macrophages. Inhibits TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. Also reduces the secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ. Antidiabetogenic; prevents IL-β and IFN-γ-induced pancreatic islet cell death in vitro.

Compound Libraries

GIT 27 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 205.21
Formula C11H11NO3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 6501-72-0
PubChem ID 10798271
InChI Key MUFJHYRCIHHATF-UHFFFAOYSA-N
Smiles O=C(CC1CC(C2=CC=CC=C2)=NO1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 205.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.87 mL 24.37 mL 48.73 mL
5 mM 0.97 mL 4.87 mL 9.75 mL
10 mM 0.49 mL 2.44 mL 4.87 mL
50 mM 0.1 mL 0.49 mL 0.97 mL

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1 Citation for GIT 27

Citations are publications that use Tocris products. Selected citations for GIT 27 include:

Saurus et al (2015) Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway. Cell Death Dis 6 e1752 PMID: 25950482


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