SC 144 hydrochloride

Pricing Availability   Qty
Description: gp130 inhibitor; blocks cytokine-triggered gp130 signaling
Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (1)

Biological Activity for SC 144 hydrochloride

SC 144 hydrochloride is an inhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. SC 144 hydrochloride induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. SC 144 hydrochloride delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

Compound Libraries for SC 144 hydrochloride

SC 144 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SC 144 hydrochloride

M. Wt 358.76
Formula C16H11FN6O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 917497-70-2
PubChem ID 66921431
InChI Key LKFGGXYXFIICED-UHFFFAOYSA-N
Smiles O=C(C4=CN=CC=N4)NNC1=NC(C=C(F)C=C3)=C3N2C1=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SC 144 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.23 100

Preparing Stock Solutions for SC 144 hydrochloride

The following data is based on the product molecular weight 358.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.94 mL 27.87 mL
5 mM 0.56 mL 2.79 mL 5.57 mL
10 mM 0.28 mL 1.39 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for SC 144 hydrochloride

Certificate of Analysis / Product Datasheet
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References for SC 144 hydrochloride

References are publications that support the biological activity of the product.

Xu et al (2013) Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol.Cancer Ther. 12 937 PMID: 23536726


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View all Cytokine Inhibitors

Keywords: SC 144 hydrochloride, SC 144 hydrochloride supplier, SC144, hydrochloride, GP130, inhibitors, inhibits, blocks, cytokine, triggered, gp130, signaling, signalling, Stat3, nuclear, translocation, ovarian, cancer, Cytokines, 4963, Tocris Bioscience

7 Citations for SC 144 hydrochloride

Citations are publications that use Tocris products. Selected citations for SC 144 hydrochloride include:

Anurag et al (2018) Exogenous melatonin protects small-for-size liver grafts by promoting monocyte infiltration and releases interleukin-6. J Pineal Res 65 e12486 PMID: 29505662

Praachi et al (2022) Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior. Eneuro 9 PMID: 35115382

Richard et al (2022) Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour. Elife 11 PMID: 35287795

Jop et al (2022) A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression. Development 149 PMID: 35993866


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Literature in this Area

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Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.