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Suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 376.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||53.13 mL||265.67 mL||531.35 mL|
|0.25 mM||10.63 mL||53.13 mL||106.27 mL|
|0.5 mM||5.31 mL||26.57 mL||53.13 mL|
|2.5 mM||1.06 mL||5.31 mL||10.63 mL|
References are publications that support the biological activity of the product.
Hao et al (2013) Inhibition of the growth factor MDK/Midkine by a novel small molecule compound to treat non-small cell lung cancer. PLoS ONE 8 e71093 PMID: 23976985
If you know of a relevant reference for iMDK, please let us know.
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Keywords: iMDK, iMDK supplier, iMDK, MDK, expression, lung, adenocarcinoma, KRAS, PI3, kinases, apoptosis, cancer, midkine, Cytokines, PI, 3-Kinase, 5126, Tocris Bioscience
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