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Description: Suppressor of MDK expression; inhibits PI 3-K signaling
Chemical Name: 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for iMDK

iMDK is a suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.

Technical Data for iMDK

M. Wt 376.4
Formula C21H13FN2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 881970-80-5
PubChem ID 15991416
Smiles FC(C=C5)=CC=C5CC4=CN1C(S4)=NC(C(C(O3)=O)=CC2=C3C=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for iMDK

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1.88 5

Preparing Stock Solutions for iMDK

The following data is based on the product molecular weight 376.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 53.13 mL 265.67 mL 531.35 mL
0.25 mM 10.63 mL 53.13 mL 106.27 mL
0.5 mM 5.31 mL 26.57 mL 53.13 mL
2.5 mM 1.06 mL 5.31 mL 10.63 mL

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Product Datasheets for iMDK

Certificate of Analysis / Product Datasheet
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References for iMDK

References are publications that support the biological activity of the product.

Hao et al (2013) Inhibition of the growth factor MDK/Midkine by a novel small molecule compound to treat non-small cell lung cancer. PLoS ONE 8 e71093 PMID: 23976985

If you know of a relevant reference for iMDK, please let us know.

Keywords: iMDK, iMDK supplier, iMDK, MDK, expression, lung, adenocarcinoma, KRAS, PI3, kinases, apoptosis, cancer, midkine, Cytokines, PI, 3-Kinase, 5126, Tocris Bioscience

1 Citation for iMDK

Citations are publications that use Tocris products. Selected citations for iMDK include:

Clara et al (2020) Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration. Elife 9 PMID: 31934849

Do you know of a great paper that uses iMDK from Tocris? Please let us know.

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