Cytokine Receptors

Cytokine receptors are a large family of receptors that are grouped into six categories based upon their three-dimensional structure. The categories are: type I, type II, immunoglobulin superfamily, tumor necrosis factor family, chemokine and TGF-β receptors.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
5372 Bioymifi
DR5 (TRAIL receptor) agonist; induces apoptosis

Antagonists

Cat No Product Name / Activity
1793 AF 12198
Potent, selective human type I IL-1 receptor antagonist
1675 YM 90709
Interleukin-5 receptor antagonist

Other

Cat No Product Name / Activity
5602 6877002
CD40-TRAF6 interaction inhibitor
2265 Lyn peptide inhibitor
Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
5432 R 7050
Inhibitor of TNF-α receptor 1 signaling
1794 Ro 26-4550 trifluoroacetate
Competitive inhibitor of IL-2/ IL-2Rα receptor interaction

Cytokine receptors are a large family of receptors that are grouped into six categories: type I, type II, immunoglobulin superfamily, tumor necrosis factor family, chemokine and TGF-β receptors.

  1. Type I cytokine receptors: include the IL-2 receptor, growth hormone receptor and erythropoietin receptor, are linked to JAK tyrosine kinases.
  2. Type II cytokine receptors: include interferon receptors are also linked to JAK tyrosine kinases.
  3. Immunoglobulin superfamily receptors: also classed as cell adhesion molecules, and family members include the IL-1 and IL-18 receptors.
  4. The tumor necrosis factor family: also known as death receptors as they have a role in the extrinsic apoptotic pathway.
  5. Chemokine receptors: G-protein-coupled receptors that have a role in innate and adaptive immunity.
  6. TGF-β receptors: serine/threonine kinase-coupled receptors with a role in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death.

Literature for Cytokine Receptors

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Cytokine Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Type I Cytokine Receptors
IL-2Rα Human IL2RA NM_000417 P01589
Mouse Il2ra NM_008367 P01590
Rat Il2ra NM_013163 P26897
IL-2Rβ Human IL2RB NM_000878 P14784
Mouse Il2rb NM_008368 P16297
Rat Il2rb NM_013195 P26896
IL-2Rγ Human IL2RG NM_000206 P31785
Mouse Il2rg NM_013563 P34902
Rat Il2rg NM_080889 Q7TP53
IL-3Rα Human IL3RA NM_002183 P26951
Mouse Il3ra NM_008369 P26952
Rat Il3ra NM_139260 Q9JM46
IL-4R Human IL4R NM_000418 Q9H187
Mouse Il4ra NM_001008700 P16382
Rat Il4ra NM_133380 Q63257
IL-5Rα Human IL5RA NM_175724 Q01344
Mouse Il5ra NM_008370 P21183
Rat Il5ra NM_053645 Q920B8
IL-6R Human IL6R NM_181359 P08887
Mouse Il6ra NM_010559 P22272
Rat Il6ra NM_017020 P22273
IL-7R Human IL7R NM_002185 P16871
Mouse Il7r NM_008372 P16872
Rat Il7r NM_001106418 XP_226824
IL-8Rα Human IL8RA NM_000634 Q8N6T6
Mouse Il8ra NM_178241 Q810W6
Rat Il8ra NM_019310 P70612
IL-8Rβ Human IL8RB NM_001557 P25025
Mouse Il8rb NM_009909 P35343
Rat Il8rb NM_017183 P35407
IL-9R Human IL9R NM_002186 Q01113
Mouse Il9r NM_001134458 Q01114
Rat Il9r NM_017021 Q63216
IL-11Rα Human IL11RA NM_004512 Q14626
Mouse Il11ra1 NM_010549 Q64385
Rat Il11ra1 NM_139116 Q99MF4
IL-12Rβ1 Human IL12RB1 NM_005535 P42701
Mouse Il12rb1 NM_008353 Q60837
Rat Il12rb1 XM_344493 Q9Z0Z2
IL-12Rβ2 Human IL12RB2 NM_001559 Q99665
Mouse Il12rb2 NM_008354 P97378
Rat Il12rb2 XM_231873 Q9Z0Z1
IL-13Rα1 Human IL13RA1 NM_001560 P78552
Mouse Il13ra1 NM_133990 O09030
Rat Il13ra1 NM_145789 Q561K3
IL-13Rα2 Human IL13RA2 NM_000640 Q14627
Mouse Il13ra2 NM_008356 NP_032382
Rat Il13ra2 NM_133538 Q8VHK6
IL-15Rα Human IL15RA NM_172200 Q13261
Mouse Il15ra NM_133836 Q60819
Rat Il15ra XM_344628 -
IL-21R Human IL21R NM_181079 Q9HBE5
Mouse Il21r NM_021887 Q9JHX3
Rat Il21r NM_001012469 Q5EBB1
IL-23R Human IL23R NM_144701 Q8IW84
Mouse Il23r NM_144548 Q8K4B4
Rat Il23r XM_001072576 XP_001072576
IL-27R Human IL27RA NM_004843 Q6UWB1
Mouse Il27ra NM_016671 O70394
Rat Il27ra NM_001105943 XP_222455
Erythropoietin Receptor Human EPOR NM_000121 P19235
Mouse Epor NM_010149 P14753
Rat Epor NM_017002 O35545
GM-CSF Receptor Human CSF2RA NM_172246 P15509
Mouse Csf2ra NM_009970 Q00941
Rat Csf2ra NM_001037660 Q701L2
G-CSF Receptor Human CSF3R NM_156039 Q99062
Mouse Csf3r NM_007782 P40223
Rat Csf3r NM_001106685 XP_233514
Growth Hormone Receptor Human GHR NM_000163 P10912
Mouse Ghr NM_010284 P16882
Rat Ghr NM_017094 P16310
Prolactin Receptor Human PRLR NM_000949 P16471
Mouse Prlr NM_011169 Q08501
Rat Prlr NM_001034111 P05710
Oncostatin M Receptor Human OSMR NM_003999 Q99650
Mouse Osmr NM_011019 O70458
Rat Osmr NM_001005384 Q65Z14
Leukemia Inhibitory Ractor Receptor Human LIFR NM_002310 P42702
Mouse Lifr NM_013584 P42703
Rat Lifr NM_031048 O70535
Type II Cytokine Receptors
Interferon Receptor α1 Human IFNAR1 NM_000629 P17181
Mouse Ifnar1 NM_010508 P33896
Rat Ifnar1 NM_001105893 XP_213649
Interferon Receptor α2 Human IFNAR2 NM_000874 P48551
Mouse Ifnar2 NM_010509 O35664
Interferon Receptor γ1 Human IFNGR1 NM_000416 P15260
Mouse Ifngr1 NM_010511 P15261
Rat Ifngr1 NM_053783 P70599
Interferon Receptor γ2 Human IFNGR2 NM_005534 P38484
Mouse Ifngr2 NM_008338 NP_032364
Rat Ifngr2 NM_001108313 XP_340968
IL-10Rα Human IL10RA NM_001558 Q13651
Mouse Il10ra NM_008348 Q61727
Rat Il10ra NM_057193 Q99ND6
IL-10Rβ Human IL10RB NM_000628 Q08334
Mouse Il10rb NM_008349 Q61190
Rat Il10rb NM_001107111 XP_221655
IL-20Rα Human IL20RA NM_014432 Q9UHF4
Mouse Il20ra NM_172786 Q6PHB0
Rat Il20ra NM_001107521 XP_218776
IL-20Rβ Human IL20RB NM_144717 Q6UXL0
Mouse Il20rb NM_001033543 NP_001028715
Rat Il20rb XM_576456 XP_576456
IL-22Rα1 Human IL22RA1 NM_021258 Q8N6P7
Mouse Il22ra1 NM_178257 Q80XZ4
Rat Il22ra1 XM_342947 XP_342948
IL-22Rα2 Human IL22RA2 NM_181309 Q969J5
Mouse Il22ra2 NM_178258 Q80XF5
Rat Il22ra2 NM_001003404 Q7TNI4
IL-28Rα Human IL28RA NM_170743 Q8IU57
Mouse Il28ra NM_174851 Q8CGK5
Rat Il28ra XM_342946 XP_342947