Selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogen, sedative-hypnotic with inherent anti-inflammatory properties. Promotes degradation of transcription factor SALL4.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 258.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||15.49 mL||77.45 mL||154.9 mL|
|1.25 mM||3.1 mL||15.49 mL||30.98 mL|
|2.5 mM||1.55 mL||7.75 mL||15.49 mL|
|12.5 mM||0.31 mL||1.55 mL||3.1 mL|
References are publications that support the biological activity of the product.
Boireau et al (1997) Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice. Neurosci.Lett. 234 123 PMID: 9364513
Kanbayashi et al (1996) Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy. Neuroreport 7 1881 PMID: 8905685
Makonkawkeyoon et al (1993) Thalidomide inhibits the replication of human-immunodeficiency-virus type 1. Proc.Natl.Acad.Sci.U.S.A. 90 5974 PMID: 8327469
Zhang et al (2008) Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma. J.Exp.Clin.Cancer Res. 27 60 PMID: 18983651
Sampaio et al (1991) Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J.Exp.Med. 173 699 PMID: 1997652
Merck Index 12 9390
Ito et al (2010) Identification of a primary target of thalidomide teratogenicity. Science 327 1345 PMID: 20223979
Donovan et al (2018) Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 7 e38430 PMID: 30067223
If you know of a relevant reference for Thalidomide, please let us know.
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Keywords: Thalidomide, Thalidomide supplier, TNF-α, TNF-alpha, synthesis, inhibitors, inhibits, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, Signaling, Signalling, teratogen, anti-inflammatory, angiogenesis, cereblon, ubiquitin, E3, ligase, SALL4, Antiangiogenics, Ubiquitin, Ligases, Active, Degraders, Other, Transcription, Factors, 0652, Tocris Bioscience
11 Citations for Thalidomide
Citations are publications that use Tocris products. Selected citations for Thalidomide include:
Helmy et al (2015) Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs. PLoS One 10 e0142303 PMID: 26536032
Eter and Spitznas (2002) DMSO mimics inhibitory effect of thalidomide on choriocapillary endothelial cell proliferation in culture. Oncol Lett 86 1303 PMID: 12386094
Sung et al (2009) Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther 8 959 PMID: 19372569
Rocha et al (2006) Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw. Br J Pharmacol 148 688 PMID: 16702985
Girgis et al (2010) Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line. MBio 1 663 PMID: 22966360
Kannappan et al (2010) γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. J Biol Chem 285 33520 PMID: 20720018
Gu et al (2010) Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model. Mol Pain 6 64 PMID: 20923560
Pandey et al (2010) Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Int J Cancer 127 282 PMID: 19937797
Sandur et al (2010) 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Mol Cancer Res 8 107 PMID: 20068065
Ahn et al (2007) Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood 110 2286 PMID: 17609425
Pathak et al (2007) Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 5 943 PMID: 17855663
Do you know of a great paper that uses Thalidomide from Tocris? Please let us know.
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Literature in this Area
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