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Description: Cereblon binder; also TNF-α inhibitor and antiangiogenic
Chemical Name: 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Citations (1)
Literature (3)

Biological Activity for Pomalidomide

Pomalidomide is a potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic. Promotes degradation of transcription factor SALL4.

Technical Data for Pomalidomide

M. Wt 273.24
Formula C13H11N3O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 19171-19-8
PubChem ID 134780
Smiles NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pomalidomide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.32 100

Preparing Stock Solutions for Pomalidomide

The following data is based on the product molecular weight 273.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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References for Pomalidomide

References are publications that support the biological activity of the product.

Lohbeck & Miller (2016) Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 26 5260 PMID: 27687673

Nanthakumar et al (2015) Dissecting fibrosis: therapeutic insights from the small-molecule toolbox. Nat.Rev.Drug.Discov. 14 693 PMID: 26338155

Lai et al (2016) Modular PROTAC design for the degradation of oncogenic BCR-ABL. Angew.Chem.Int.Ed.Engl. 55 807 PMID: 26593377

Winter et al (2015) Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 348 1376 PMID: 25999370

Donovan et al (2018) Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 7 e38430 PMID: 30067223

Chamberlain et al (2019) Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett. 10 1592 PMID: 31857833

If you know of a relevant reference for Pomalidomide, please let us know.

Keywords: Pomalidomide, Pomalidomide supplier, Pomalidomide, TNFa, TNFalpha, TNFα, Inhibitors, inhibits, IL-2, thalidomide, cereblon, binder, ubiquitination, antiproliferative, antiangiogenic, lymphoma, SALL4, CELMoD, E3, ligase, modulators, immunomodulators, immunomodulatory, imide, IMiDs, Ubiquitin, Ligases, Cytokines, Antiangiogenics, Other, Transcription, Factors, Molecular, Glues, 6302, Tocris Bioscience

1 Citation for Pomalidomide

Citations are publications that use Tocris products. Selected citations for Pomalidomide include:

Francisca et al (2022) Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun 13 5495 PMID: 36127368

Do you know of a great paper that uses Pomalidomide from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia