Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
CGI 1746 is a potent, reversible inhibitor of Bruton's tyrosine kinase (Btk) (IC50 = 1.9 nM). CGI 1746 decreases cell survival in prostate cancer cell lines. In a cell model, CGI 1746 blocks the production of FcγR-induced cytokines IL-1β, TNFα and IL-6 (IC50 values are 36 nM, 47 nM and 353 nM, respectively).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 579.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.63 mL||43.13 mL||86.25 mL|
|1 mM||1.73 mL||8.63 mL||17.25 mL|
|2 mM||0.86 mL||4.31 mL||8.63 mL|
|10 mM||0.17 mL||0.86 mL||1.73 mL|
References are publications that support the biological activity of the product.
Di Paolo et al (2011) Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat.Chem.Biol. 7 41 PMID: 21113169
Kokabee et al (2015) Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol. Ther. 16 1604 PMID: 26383180
If you know of a relevant reference for CGI 1746, please let us know.
Keywords: CGI 1746, CGI 1746 supplier, CGI1746, potent, reversible, inhibitors, inhibits, brutons, tyrosines, kinases, Btk, cytokines, prostate, cancer, IL1beta, TNFalpha, interleukins, tumour, necrosis, factor, Brutons, Tyrosine, Kinase, (BTK), Cytokines, 6965, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for CGI 1746. Do you know of a great paper that uses CGI 1746 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review CGI 1746 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.