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Biological Activity for CGI 1746
CGI 1746 is a potent, reversible inhibitor of Bruton's tyrosine kinase (Btk) (IC50 = 1.9 nM). CGI 1746 decreases cell survival in prostate cancer cell lines. In a cell model, CGI 1746 blocks the production of FcγR-induced cytokines IL-1β, TNFα and IL-6 (IC50 values are 36 nM, 47 nM and 353 nM, respectively).
Technical Data for CGI 1746
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CGI 1746
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CGI 1746
The following data is based on the product molecular weight 579.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.63 mL||43.13 mL||86.25 mL|
|1 mM||1.73 mL||8.63 mL||17.25 mL|
|2 mM||0.86 mL||4.31 mL||8.63 mL|
|10 mM||0.17 mL||0.86 mL||1.73 mL|
References for CGI 1746
References are publications that support the biological activity of the product.
Di Paolo et al (2011) Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat.Chem.Biol. 7 41 PMID: 21113169
Kokabee et al (2015) Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol. Ther. 16 1604 PMID: 26383180
If you know of a relevant reference for CGI 1746, please let us know.
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Citations for CGI 1746
Citations are publications that use Tocris products.
Currently there are no citations for CGI 1746. Do you know of a great paper that uses CGI 1746 from Tocris? Please let us know.
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Literature in this Area
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