UCLA GP130 2

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Cat.No. 6583 - UCLA GP130 2 | C15H11FN2S | CAS No. 339303-87-6
Description: gp130 agonist; brain penetrant and neuroprotectant
Chemical Name: N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

gp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant.

Technical Data

M. Wt 270.32
Formula C15H11FN2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 339303-87-6
PubChem ID 1284592
InChI Key HXVFUSRCVKYALB-UHFFFAOYSA-N
Smiles FC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.03 100
ethanol 27.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 270.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 36.99 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem.Neurosci. 9 462 PMID: 29161500


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