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Description: Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)
Literature (3)

Biological Activity for Lenalidomide

Lenalidomide is a thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4CRBN. Also TNF-α inhibitor and angiogenesis inhibitor. Promotes degradation of transcription factor SALL4.

Compound Libraries for Lenalidomide

Lenalidomide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Lenalidomide

M. Wt 259.26
Formula C13H13N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 191732-72-6
PubChem ID 216326
Smiles NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lenalidomide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.93 100

Preparing Stock Solutions for Lenalidomide

The following data is based on the product molecular weight 259.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.57 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets for Lenalidomide

Certificate of Analysis / Product Datasheet
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References for Lenalidomide

References are publications that support the biological activity of the product.

Petzold et al (2016) Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 532 127 PMID: 26909574

Krönke et al (2015) Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 523 183 PMID: 26131937

Donovan et al (2018) Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 7 e38430 PMID: 30067223

Chamberlain et al (2019) Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett. 10 1592 PMID: 31857833

If you know of a relevant reference for Lenalidomide, please let us know.

Keywords: Lenalidomide, Lenalidomide supplier, tumor, necrosis, factor, 1α, alpha, alfa, TNF, angiogenesis, inhibitor, cereblon, binder, ubiquitin, CELMoD, E3, ligase, modulators, SALL4, casein, kinase, CK1, degrades, immunomodulators, immunomodulatory, imide, IMiDs, molecular, glue, modulating, CELMoDs, Ubiquitin, Ligases, Cytokines, Antiangiogenics, Other, Transcription, Factors, Molecular, Glues, 6305, Tocris Bioscience

1 Citation for Lenalidomide

Citations are publications that use Tocris products. Selected citations for Lenalidomide include:

Fang et al (2020) Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism. Oncotarget 11 4224-4242 PMID: 33245718

Do you know of a great paper that uses Lenalidomide from Tocris? Please let us know.

Reviews for Lenalidomide

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Lenalidomide as Ikaros inhibitor.
By Binod G C on 05/06/2021
Species: Human
Cell Line/Tissue: Ba/F

Lenalidomide was used to inhibit Ikaros to examine target gene expression. 2um concentration was used.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia