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Thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4CRBN. Also TNF-α inhibitor and angiogenesis inhibitor. Promotes degradation of transcription factor SALL4.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 259.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.86 mL||19.29 mL||38.57 mL|
|5 mM||0.77 mL||3.86 mL||7.71 mL|
|10 mM||0.39 mL||1.93 mL||3.86 mL|
|50 mM||0.08 mL||0.39 mL||0.77 mL|
References are publications that support the biological activity of the product.
Petzold et al (2016) Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 532 127 PMID: 26909574
Krönke et al (2015) Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 523 183 PMID: 26131937
Donovan et al (2018) Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 7 e38430 PMID: 30067223
Chamberlain et al (2019) Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett. 10 1592 PMID: 31857833
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Keywords: Lenalidomide, Lenalidomide supplier, tumor, necrosis, factor, 1α, alpha, alfa, TNF, angiogenesis, inhibitor, cereblon, binder, ubiquitin, CELMoD, E3, ligase, modulators, SALL4, casein, kinase, CK1, degrades, immunomodulators, immunomodulatory, imide, IMiDs, molecular, glue, modulating, CELMoDs, Ubiquitin, Ligases, Cytokines, Antiangiogenics, Other, Transcription, Factors, Molecular, Glues, 6305, Tocris Bioscience
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Literature in this Area
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