Lenalidomide

Pricing Availability   Qty
Cat.No. 6305 - Lenalidomide | C13H13N3O3 | CAS No. 191732-72-6
Description: Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4CRBN. Also TNF-α inhibitor and angiogenesis inhibitor. Promotes degradation of transcription factor SALL4.

Technical Data

M. Wt 259.26
Formula C13H13N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 191732-72-6
PubChem ID 216326
InChI Key GOTYRUGSSMKFNF-UHFFFAOYSA-N
Smiles NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 259.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.57 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Petzold et al (2016) Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 532 127 PMID: 26909574

Krönke et al (2015) Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 523 183 PMID: 26131937

Donovan et al (2018) Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 7 e38430 PMID: 30067223


If you know of a relevant reference for Lenalidomide, please let us know.

Keywords: Lenalidomide, Lenalidomide supplier, tumor, necrosis, factor, 1α, alpha, TNF, angiogenesis, inhibitor, cereblon, binder, ubiquitin, E3, ligase, SALL4, Ubiquitin, Ligases, Cytokines, Antiangiogenics, PROTACs, Other, Transcription, Factors, 6305, Tocris Bioscience

Citations for Lenalidomide

Citations are publications that use Tocris products.

Currently there are no citations for Lenalidomide. Do you know of a great paper that uses Lenalidomide from Tocris? Please let us know.

Reviews for Lenalidomide

There are currently no reviews for this product. Be the first to review Lenalidomide and earn rewards!

Have you used Lenalidomide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.