Lenalidomide

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Cat.No. 6305 - Lenalidomide | C13H13N3O3 | CAS No. 191732-72-6
Description: Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4CRBN. Also TNF-α inhibitor and angiogenesis inhibitor.

Technical Data

M. Wt 259.26
Formula C13H13N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 191732-72-6
PubChem ID 216326
InChI Key GOTYRUGSSMKFNF-UHFFFAOYSA-N
Smiles NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 259.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.57 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Petzold et al (2016) Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 532 127 PMID: 26909574

Krönke et al (2015) Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 523 183 PMID: 26131937


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Keywords: Lenalidomide, supplier, tumor, necrosis, factor, 1α, alpha, TNF, angiogenesis, inhibitor, cereblon, binder, ubiquitin, E3, ligase, Ubiquitin, E3, Ligases, Cytokines, Antiangiogenics, Ubiquitin, E3, Ligases, Tocris Bioscience

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