Pricing Availability   Qty
Description: MIF binder
Chemical Name: 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for BTZO 1

BTZO 1 binds macrophage migration inhibitory factor (MIF; Kd = 68.6 nM) and activates antioxidant response element (ARE)-mediated gene expression. BTZO 1 suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro and is cardioprotective.

External Portal Information for BTZO 1 and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of BTZO 1 is reviewed on and the SGC website.

Compound Libraries for BTZO 1

BTZO 1 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BTZO 1

M. Wt 240.28
Formula C13H8N2OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99420-15-2
PubChem ID 9837640
Smiles O=C2C1=CC=CC=C1SC(C3=NC=CC=C3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BTZO 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.81 20 with gentle warming

Preparing Stock Solutions for BTZO 1

The following data is based on the product molecular weight 240.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 20.81 mL 104.05 mL 208.09 mL
1 mM 4.16 mL 20.81 mL 41.62 mL
2 mM 2.08 mL 10.4 mL 20.81 mL
10 mM 0.42 mL 2.08 mL 4.16 mL

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References for BTZO 1

References are publications that support the biological activity of the product.

Kimura et al (2010) BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 17 1282 PMID: 21168764

If you know of a relevant reference for BTZO 1, please let us know.

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Keywords: BTZO 1, BTZO 1 supplier, BTZO1, mif, macrophage, migration, inhibitory, factors, binders, binds, cardioprotective, Cytokines, 4204, Tocris Bioscience

Citations for BTZO 1

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Literature in this Area

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