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Biological Activity for BTZO 1
BTZO 1 binds macrophage migration inhibitory factor (MIF; Kd = 68.6 nM) and activates antioxidant response element (ARE)-mediated gene expression. BTZO 1 suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro and is cardioprotective.
External Portal Information for BTZO 1
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of BTZO 1 is reviewed on chemicalprobes.org and the SGC website.
Compound Libraries for BTZO 1
Technical Data for BTZO 1
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BTZO 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.81||20 with gentle warming|
Preparing Stock Solutions for BTZO 1
The following data is based on the product molecular weight 240.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||20.81 mL||104.05 mL||208.09 mL|
|1 mM||4.16 mL||20.81 mL||41.62 mL|
|2 mM||2.08 mL||10.4 mL||20.81 mL|
|10 mM||0.42 mL||2.08 mL||4.16 mL|
References for BTZO 1
References are publications that support the biological activity of the product.
Kimura et al (2010) BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 17 1282 PMID: 21168764
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Citations for BTZO 1
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.