BTZO 1

Pricing Availability   Qty
Cat.No. 4204 - BTZO 1 | C13H8N2OS | CAS No. 99420-15-2
Description: MIF binder
Chemical Name: 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). Activates antioxidant response element (ARE)-mediated gene expression. Suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Cardioprotective.

Technical Data

M. Wt 240.28
Formula C13H8N2OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99420-15-2
PubChem ID 9837640
InChI Key GBAKVEWPYUIGHN-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1SC(C3=NC=CC=C3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.81 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 240.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 20.81 mL 104.05 mL 208.09 mL
1 mM 4.16 mL 20.81 mL 41.62 mL
2 mM 2.08 mL 10.4 mL 20.81 mL
10 mM 0.42 mL 2.08 mL 4.16 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Kimura et al (2010) BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 17 1282 PMID: 21168764


If you know of a relevant reference for BTZO 1, please let us know.

View Related Products by Target

Keywords: BTZO 1, BTZO 1 supplier, BTZO1, mif, macrophage, migration, inhibitory, factors, binders, binds, cardioprotective, Cytokines, 4204, Tocris Bioscience

Citations for BTZO 1

Citations are publications that use Tocris products.

Currently there are no citations for BTZO 1. Do you know of a great paper that uses BTZO 1 from Tocris? Please let us know.

Reviews for BTZO 1

There are currently no reviews for this product. Be the first to review BTZO 1 and earn rewards!

Have you used BTZO 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.