BTZO 1

Pricing Availability Delivery Time Qty
Cat.No. 4204 - BTZO 1 | C13H8N2OS | CAS No. 99420-15-2
Description: MIF binder
Chemical Name: 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). Activates antioxidant response element (ARE)-mediated gene expression. Suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Cardioprotective.

Technical Data

M. Wt 240.28
Formula C13H8N2OS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 99420-15-2
PubChem ID 9837640
InChI Key GBAKVEWPYUIGHN-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1SC(C3=NC=CC=C3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.81 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 240.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.16 mL 20.81 mL 41.62 mL
5 mM 0.83 mL 4.16 mL 8.32 mL
10 mM 0.42 mL 2.08 mL 4.16 mL
50 mM 0.08 mL 0.42 mL 0.83 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kimura et al (2010) BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 17 1282 PMID: 21168764


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Keywords: BTZO1 mif macrophage migration inhibitory factors binders binds cardioprotective Cytokines

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