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Description: Antifibrotic agent; regulates cytokine levels in vivo
Chemical Name: 5-methyl-1-phenyl-2(1H)-pyridinone
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Pirfenidone

Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.

Technical Data for Pirfenidone

M. Wt 185.23
Formula C12H11NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53179-13-8
PubChem ID 40632
Smiles CC1=CN(C(=O)C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pirfenidone

Solvent Max Conc. mg/mL Max Conc. mM
water 3.7 20

Preparing Stock Solutions for Pirfenidone

The following data is based on the product molecular weight 185.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 26.99 mL 134.97 mL 269.93 mL
1 mM 5.4 mL 26.99 mL 53.99 mL
2 mM 2.7 mL 13.5 mL 26.99 mL
10 mM 0.54 mL 2.7 mL 5.4 mL

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Product Datasheets for Pirfenidone

Certificate of Analysis / Product Datasheet
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References for Pirfenidone

References are publications that support the biological activity of the product.

Iyer et al (1999) Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleo. hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 289 211 PMID: 10087006

Kehrer and Margolin (1997) Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 90 125 PMID: 9067480

Mei et al (2005) Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 313 379 PMID: 15608079

Oku et al (2002) Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 446 167 PMID: 12098599

If you know of a relevant reference for Pirfenidone, please let us know.

View Related Products by Target

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1 Citation for Pirfenidone

Citations are publications that use Tocris products. Selected citations for Pirfenidone include:

Griffiths (2018) Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis. Sci Rep 8 3212 PMID: 29453386

Do you know of a great paper that uses Pirfenidone from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.