Pirfenidone

Pricing Availability Delivery Time Qty
Cat.No. 1093 - Pirfenidone | C12H11NO | CAS No. 53179-13-8
Description: Antifibrotic agent; regulates cytokine levels in vivo
Chemical Name: 5-methyl-1-phenyl-2(1H)-pyridinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.

Technical Data

M. Wt 185.23
Formula C12H11NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53179-13-8
PubChem ID 40632
InChI Key ISWRGOKTTBVCFA-UHFFFAOYSA-N
Smiles CC1=CN(C(=O)C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 18.52 100
water 3.7 20

Preparing Stock Solutions

The following data is based on the product molecular weight 185.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.4 mL 26.99 mL 53.99 mL
5 mM 1.08 mL 5.4 mL 10.8 mL
10 mM 0.54 mL 2.7 mL 5.4 mL
50 mM 0.11 mL 0.54 mL 1.08 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Iyer et al (1999) Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 289 211 PMID: 10087006

Kehrer and Margolin (1997) Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 90 125 PMID: 9067480

Mei et al (2005) Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 313 379 PMID: 15608079

Oku et al (2002) Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 446 167 PMID: 12098599


If you know of a relevant reference for Pirfenidone, please let us know.

View Related Products by Target

Keywords: Antifibrotic agent regulates cytokine levels vivo TNF-α TNF-alpha Interleukins Tumor Necrosis Factor-α Factor-alpha Cytokines Cytokine NF-κB NF-kappaB Signaling Signalling esbriet Cytokines

Citations for Pirfenidone

Citations are publications that use Tocris products.

Currently there are no citations for Pirfenidone. Do you know of a great paper that uses Pirfenidone from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for Pirfenidone

Protocols

TODO: Add Protocols