Pirfenidone

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Cat.No. 1093 - Pirfenidone | C12H11NO | CAS No. 53179-13-8
Description: Antifibrotic agent; regulates cytokine levels in vivo
Chemical Name: 5-methyl-1-phenyl-2(1H)-pyridinone
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.

Technical Data

M. Wt 185.23
Formula C12H11NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53179-13-8
PubChem ID 40632
InChI Key ISWRGOKTTBVCFA-UHFFFAOYSA-N
Smiles CC1=CN(C(=O)C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.7 20

Preparing Stock Solutions

The following data is based on the product molecular weight 185.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.4 mL 26.99 mL 53.99 mL
5 mM 1.08 mL 5.4 mL 10.8 mL
10 mM 0.54 mL 2.7 mL 5.4 mL
50 mM 0.11 mL 0.54 mL 1.08 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Iyer et al (1999) Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 289 211 PMID: 10087006

Kehrer and Margolin (1997) Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 90 125 PMID: 9067480

Mei et al (2005) Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 313 379 PMID: 15608079

Oku et al (2002) Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 446 167 PMID: 12098599


If you know of a relevant reference for Pirfenidone, please let us know.

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1 Citation for Pirfenidone

Citations are publications that use Tocris products. Selected citations for Pirfenidone include:

Griffiths (2018) Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis. Sci Rep 8 3212 PMID: 29453386


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Reviews for Pirfenidone

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Literature in this Area

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