Trofinetide

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Description: IGF-1 synthetic analogue
Chemical Name: Glycyl-2-methyl-L-prolyl-L-glutamic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity for Trofinetide

Trofinetide is an IGF-1 synthetic analog. It suppresses expression of IL-1β, TNF-α, IFN-γ and E-selectin, and inhibits both acute and delayed neuroinflammation following penetrating ballistic-like brain injury (PBBI) in rats.

Technical Data for Trofinetide

M. Wt 315.32
Formula C13H21N3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 853400-76-7
InChI Key BUSXWGRAOZQTEY-SDBXPKJASA-N
Smiles C(N[C@@H](CCC(O)=O)C(O)=O)(=O)[C@@]1(C)N(C(CN)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Trofinetide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.53 100
DMSO 15.77 50 with gentle warming

Preparing Stock Solutions for Trofinetide

The following data is based on the product molecular weight 315.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.86 mL 31.71 mL
5 mM 0.63 mL 3.17 mL 6.34 mL
10 mM 0.32 mL 1.59 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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References for Trofinetide

References are publications that support the biological activity of the product.

Wei et al (2009) NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J.Neuroinflammation 6 19 PMID: 19656406


If you know of a relevant reference for Trofinetide, please let us know.

Keywords: Trofinetide, Trofinetide supplier, IGF1, synthetic, analogue, in, vivo, cytokine, inflammatory, IL-1β, IFN-γ, E-selectin, neuroinflammation, PBBI, penetrating, ballistic-like, brain, injury, NNZ-2566, NNZ2566, Insulin, and, insulin-like, Receptors, Cytokines, 7937, Tocris Bioscience

Citations for Trofinetide

Citations are publications that use Tocris products.

Currently there are no citations for Trofinetide. Do you know of a great paper that uses Trofinetide from Tocris? Please let us know.

Reviews for Trofinetide

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Trofinetide

Insulin Signaling Pathway

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.