Chemokine Receptors

Chemokine receptors are 7-transmembrane G protein-coupled receptors that are activated by the binding of one or more chemokines. Chemokines are a family of chemoattractant molecules with more than 50 having been identified to date. They are categorized according to the number and spacing of conserved cysteines into four main groups: CXC, CC, CX3C and C.

Targets
Literature

Chemokine Receptor Target Files

Related Targets

    Chemokine receptors are found predominantly on leukocytes and are important in leukocyte trafficking, as well as leukocyte-dependent processes such as immune surveillance, immune response and pathological inflammation. Chemokines have a role in angiogenesis, apoptosis, T-cell differentiation and phagocyte activation, while inappropriate or prolonged expression of chemokines and their receptors can lead to autoimmune disease by incorrectly targeting self antigens for destruction by cytotoxic T-cells and macrophages.

    There are 19 chemokine receptors and each one has a distinct chemokine and leukocyte specificity, although these specificities can overlap, with a single receptor being able to bind multiple ligands, while a single ligand may be able to bind multiple receptors. In addition, different receptors coexpressed in the same cell may induce the same response and, conversely a single receptor may be able to distinguish activation by different ligands leading to activation of distinct signaling pathways.

    Literature for Chemokine Receptors

    GPCR

    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Secretin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
    • GPCR Signaling
    Immunology

    Immunology Product Listing

    A collection of over 190 products for immunology research, the guide includes research tools for the study of:

    • Chemokine and Cytokine Signaling
    • Chemotaxis
    • Complement System
    • Immune Cell Signaling
    • Inflammation
    Asthma

    Asthma Poster

    Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.