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Chemokine receptors are 7-transmembrane G protein-coupled receptors that are activated by the binding of one or more chemokines. Chemokines are a family of chemoattractant molecules with more than 50 having been identified to date. They are categorized according to the number and spacing of conserved cysteines into four main groups: CXC, CC, CX3C and C.
Chemokine receptors are found predominantly on leukocytes and are important in leukocyte trafficking, as well as leukocyte-dependent processes such as immune surveillance, immune response and pathological inflammation. Chemokines have a role in angiogenesis, apoptosis, T-cell differentiation and phagocyte activation, while inappropriate or prolonged expression of chemokines and their receptors can lead to autoimmune disease by incorrectly targeting self antigens for destruction by cytotoxic T-cells and macrophages.
There are 19 chemokine receptors and each one has a distinct chemokine and leukocyte specificity, although these specificities can overlap, with a single receptor being able to bind multiple ligands, while a single ligand may be able to bind multiple receptors. In addition, different receptors coexpressed in the same cell may induce the same response and, conversely a single receptor may be able to distinguish activation by different ligands leading to activation of distinct signaling pathways.
Tocris offers the following scientific literature for Chemokine Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.