JTE 607 dihydrochloride
Cytokine release inhibitor. Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 597.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.67 mL||8.37 mL||16.74 mL|
|5 mM||0.33 mL||1.67 mL||3.35 mL|
|10 mM||0.17 mL||0.84 mL||1.67 mL|
|50 mM||0.03 mL||0.17 mL||0.33 mL|
References are publications that support the products' biological activity.
Kakutani et al (1999) JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm.Res. 48 461 PMID: 10493164
Jian (2004) JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats. Eur.J.Pharmacol. 488 231 PMID: 15044056
Tajima et al (2010) JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci. 101 774 PMID: 20028380
If you know of a relevant reference for JTE 607 dihydrochloride, please let us know.
Keywords: JTE 607 dihydrochloride, supplier, JTE607, dihydrochloride, cytokines, inhibitors, inhibits, TNFa, TNF-alpha, TNF-α, interleukins, IL-1beta, IL-1b, IL-1β, inflammation, anti-inflammatory, IL-6, IL-8, IL-10, apoptosis, Cytokines, Cytokines, Tocris Bioscience
Citations for JTE 607 dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for JTE 607 dihydrochloride. Do you know of a great paper that uses JTE 607 dihydrochloride from Tocris? If so please let us know.
JTE 607 dihydrochloride Reviews
Average Rating:(Based on 0 Reviews)
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.