ER 27319 maleate

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Cat.No. 2471 - ER 27319 maleate | C18H20N2O.C4H4O4 | CAS No. 1204480-26-1
Description: Selective Syk kinase inhibitor
Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.

Compound Libraries

ER 27319 maleate is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 396.17
Formula C18H20N2O.C4H4O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 1204480-26-1
PubChem ID 56972172
InChI Key WVUQPGFRFBVJKH-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.CC1=C(C)C2=C(C=C1)C(=O)C1=CC=CC=C1N2CCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.62 100
water 29.71 75

Preparing Stock Solutions

The following data is based on the product molecular weight 396.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.62 mL 25.24 mL
5 mM 0.5 mL 2.52 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Luskova and Draber (2004) Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des. 10 1727 PMID: 15180535

Moriya et al (1997) ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA 94 12539 PMID:


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View all Syk Kinase Inhibitors

Keywords: ER 27319 maleate, supplier, Selective, Syk, kinases, inhibitors, inhibits, TNF-α, TNF-alpha, production, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, ER27319, maleate, Syk, Kinase, Cytokines, Syk, Kinase, Tocris Bioscience

1 Citation for ER 27319 maleate

Citations are publications that use Tocris products. Selected citations for ER 27319 maleate include:

Ng et al (2008) Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29 807 PMID: 18993083


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