ER 27319 maleate

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Cat.No. 2471 - ER 27319 maleate | C18H20N2O.C4H4O4 | CAS No. 1204480-26-1
Description: Selective Syk kinase inhibitor
Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (3)

Biological Activity

Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.

Compound Libraries

ER 27319 maleate is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 396.17
Formula C18H20N2O.C4H4O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 1204480-26-1
PubChem ID 56972172
InChI Key WVUQPGFRFBVJKH-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.CC1=C(C)C2=C(C=C1)C(=O)C1=CC=CC=C1N2CCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.71 75
DMSO 39.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 396.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.62 mL 25.24 mL
5 mM 0.5 mL 2.52 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References

References are publications that support the biological activity of the product.

Luskova and Draber (2004) Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des. 10 1727 PMID: 15180535

Moriya et al (1997) ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA 94 12539


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View all Syk Kinase Inhibitors

Keywords: ER 27319 maleate, ER 27319 maleate supplier, Selective, Syk, kinases, inhibitors, inhibits, TNF-α, TNF-alpha, production, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, ER27319, maleate, Kinase, 2471, Tocris Bioscience

2 Citations for ER 27319 maleate

Citations are publications that use Tocris products. Selected citations for ER 27319 maleate include:

Rycaj et al (2016) Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA-/lo castration-resistant cells. Oncotarget 7 14220 PMID: 26871947

Ng et al (2008) Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29 807 PMID: 18993083


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Reviews for ER 27319 maleate

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Potential candidate to control for expression of the protein of interest.
By Anonymous on 01/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HeLa

In-vitro luciferase assay


Literature in this Area

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