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Cat.No. 4316 - Bropirimine | C10H8BrN3O | CAS No. 56741-95-8
Description: Immunomodulatory and antitumor compound
Chemical Name: 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity

Immunomodulatory and antitumor compound. Induces interferon (IFN)-α/β production; augments natural killer (NK) cell activity. Orally active.

Technical Data

M. Wt 266.09
Formula C10H8BrN3O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 56741-95-8
PubChem ID 65457
Smiles O=C1N=C(N)NC(C2=CC=CC=C2)=C1Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.61 100

Preparing Stock Solutions

The following data is based on the product molecular weight 266.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.76 mL 18.79 mL 37.58 mL
5 mM 0.75 mL 3.76 mL 7.52 mL
10 mM 0.38 mL 1.88 mL 3.76 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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References are publications that support the biological activity of the product.

Fujioka et al (1995) Antitumor effects of oral administration of an IF.-inducing pyrimidinone, Bropirimine, on murine renal-cell carcinoma. Cancer Chemother.Pharmacol. 36 7 PMID: 7536641

Tei et al (2002) In vitro antitumor activity of bropirimine against urinary bladder tumor cells. Anticancer Res. 22 1667 PMID: 12168852

If you know of a relevant reference for Bropirimine, please let us know.

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Keywords: Bropirimine, Bropirimine supplier, immunomodulators, immunomodulatory, antitumor, induces, interferons, ifn-a, ifn-alpha, ifn-α, ifn-b, ifn-beta, ifn-β, inducers, IFN, Cytokines, 4316, Tocris Bioscience

Citations for Bropirimine

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