Immunomodulatory and antitumor compound. Induces interferon (IFN)-α/β production; augments natural killer (NK) cell activity. Orally active.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 266.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.76 mL||18.79 mL||37.58 mL|
|5 mM||0.75 mL||3.76 mL||7.52 mL|
|10 mM||0.38 mL||1.88 mL||3.76 mL|
|50 mM||0.08 mL||0.38 mL||0.75 mL|
References are publications that support the biological activity of the product.
Fujioka et al (1995) Antitumor effects of oral administration of an interferon-inducing pyrimidinone, Bropirimine, on murine renal-cell carcinoma. Cancer Chemother.Pharmacol. 36 7 PMID: 7536641
Tei et al (2002) In vitro antitumor activity of bropirimine against urinary bladder tumor cells. Anticancer Res. 22 1667 PMID: 12168852
If you know of a relevant reference for Bropirimine, please let us know.
Keywords: Bropirimine, Bropirimine supplier, immunomodulators, immunomodulatory, antitumor, induces, interferons, ifn-a, ifn-alpha, ifn-α, ifn-b, ifn-beta, ifn-β, inducers, IFN, Cytokines, 4316, Tocris Bioscience
Citations for Bropirimine
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.