Pricing Availability   Qty
Description: Immunomodulatory and antitumor compound
Chemical Name: 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone
Purity: ≥99% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for Bropirimine

Bropirimine is a immunomodulatory and antitumor compound. Induces interferon (IFN)-α/β production; augments natural killer (NK) cell activity. Orally active.

Technical Data for Bropirimine

M. Wt 266.09
Formula C10H8BrN3O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 56741-95-8
PubChem ID 65457
Smiles O=C1N=C(N)NC(C2=CC=CC=C2)=C1Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bropirimine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.61 100

Preparing Stock Solutions for Bropirimine

The following data is based on the product molecular weight 266.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.76 mL 18.79 mL 37.58 mL
5 mM 0.75 mL 3.76 mL 7.52 mL
10 mM 0.38 mL 1.88 mL 3.76 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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References for Bropirimine

References are publications that support the biological activity of the product.

Fujioka et al (1995) Antitumor effects of oral administration of an IF.-inducing pyrimidinone, Bropirimine, on murine renal-cell carcinoma. Cancer Chemother.Pharmacol. 36 7 PMID: 7536641

Tei et al (2002) In vitro antitumor activity of bropirimine against urinary bladder tumor cells. Anticancer Res. 22 1667 PMID: 12168852

If you know of a relevant reference for Bropirimine, please let us know.

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Keywords: Bropirimine, Bropirimine supplier, immunomodulators, immunomodulatory, antitumor, induces, interferons, ifn-a, ifn-alpha, ifn-α, ifn-b, ifn-beta, ifn-β, inducers, IFN, Cytokines, 4316, Tocris Bioscience

Citations for Bropirimine

Citations are publications that use Tocris products.

Currently there are no citations for Bropirimine. Do you know of a great paper that uses Bropirimine from Tocris? Please let us know.

Reviews for Bropirimine

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Immuno-therapeutic effect of Bropirimine was studied.
By Anonymous on 12/01/2019
Species: Human

Immuno-therapeutic effect of Bropirimine was studied against other immunomodulatory imide drugs.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.