4-IPP

Pricing Availability Delivery Time Qty
Cat.No. 3429 - 4-IPP | C10H7IN2 | CAS No. 41270-96-6
Description: Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
Chemical Name: 4-Iodo-6-phenylpyrimidine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.

Technical Data

M. Wt 282.08
Formula C10H7IN2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 41270-96-6
PubChem ID 817368
InChI Key ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Smiles IC1=NC=NC(C2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.21 100
ethanol 14.1 50

Preparing Stock Solutions

The following data is based on the product molecular weight 282.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.73 mL 35.45 mL
5 mM 0.71 mL 3.55 mL 7.09 mL
10 mM 0.35 mL 1.77 mL 3.55 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Winner et al (2008) A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 68 7253 PMID: 18794110


If you know of a relevant reference for 4-IPP, please let us know.

View Related Products by Target

Keywords: macrophage migration inhibitory factors MIF inhibitors inhibits suicide substrates cytokines 4IPP Cytokines

2 Citations for 4-IPP

Citations are publications that use Tocris products. Selected citations for 4-IPP include:

Subbannayya et al (2015) Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. J Biol Chem 15 843 PMID: 26530123

Salazar et al (2014) The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation. Mol Cancer 13 198 PMID: 25168820


Do you know of a great paper that uses 4-IPP from Tocris? If so please let us know.

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Pathways for 4-IPP

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