4-IPP

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Cat.No. 3429 - 4-IPP | C10H7IN2 | CAS No. 41270-96-6
Description: Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
Chemical Name: 4-Iodo-6-phenylpyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.

Technical Data

M. Wt 282.08
Formula C10H7IN2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 41270-96-6
PubChem ID 817368
InChI Key ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Smiles IC1=NC=NC(C2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.21 100
ethanol 14.1 50

Preparing Stock Solutions

The following data is based on the product molecular weight 282.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.73 mL 35.45 mL
5 mM 0.71 mL 3.55 mL 7.09 mL
10 mM 0.35 mL 1.77 mL 3.55 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Winner et al (2008) A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 68 7253 PMID: 18794110


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View Related Products by Target

Keywords: 4-IPP, 4-IPP supplier, macrophage, migration, inhibitory, factors, MIF, inhibitors, inhibits, suicide, substrates, cytokines, 4IPP, Cytokines, 3429, Tocris Bioscience

3 Citations for 4-IPP

Citations are publications that use Tocris products. Selected citations for 4-IPP include:

Subbannayya et al (2015) Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. J Biol Chem 15 843 PMID: 26530123

Salazar et al (2014) The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation. Mol Cancer 13 198 PMID: 25168820

Takahashi et al (2013) Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses. PLoS One 8 e78250 PMID: 24167613


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