Gabexate mesylate

Pricing Availability   Qty
Description: Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin
Alternative Names: FOY
Chemical Name: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate
Purity: ≥98% (HPLC)

Biological Activity for Gabexate mesylate

Gabexate mesylate is a serine protease inhibitor; Gabexate mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Gabexate mesylate also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Gabexate mesylate attenuates allergen-induced airway inflammation and eosinophils infiltration in the lung of asthma murine model.

Technical Data for Gabexate mesylate

M. Wt 417.48
Formula C16H23N3O4.CH3SO3H
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 56974-61-9
PubChem ID 6604915
Smiles CS(O)(=O)=O.CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Gabexate mesylate

Solvent Max Conc. mg/mL Max Conc. mM
water 41.75 100

Preparing Stock Solutions for Gabexate mesylate

The following data is based on the product molecular weight 417.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 11.98 mL 23.95 mL
5 mM 0.48 mL 2.4 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for Gabexate mesylate

Certificate of Analysis / Product Datasheet
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Keywords: Gabexate mesylate, Gabexate mesylate supplier, Serine, protease, inhibits, inhibitors, thrombin, trypsin, kallikrein, plasmin, TNF-α, TNF-alpha, production, antithrombotic, agent, Proteases, Proteinases, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, PAR, Receptors, Protease-Activated, proteinase, FOY, Other, 1798, Tocris Bioscience

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