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Induced pluripotent stem cells (iPS cells or iPSCs) can be reprogrammed into human cardiomyocyte-like cells, with the aim of being used to repair damaged tissue caused by myocardial infarction to support heart regeneration. In vivo studies have generated promising results showing proof of principle for regenerative stem cell therapy.
|Cat. No.||Product Name / Activity|
|Promotes cardiomyocyte differentiation from mESCs; also histone acetyltransferase (HAT) inhibitor|
|DNA methyltransferase inhibitor; induces differentiation of MSCs into cardiomyocytes|
|Promotes cardiomyocyte differentiation in mouse ESCs; BMP type I receptor inhibitor|
|KCa activator; promotes ESC differentiation into cardiomyocytes|
|Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation|
|Selective inhibitor of TGF-beta signaling; induces cardiomyocyte differentiation in ESCs|
|Promotes promotes cardiomyocyte differentiation from hPSCs; PORCN inhibitor|
|Potent inhibitor of Wnt/β-catenin signaling; induces cardiomyocyte differentiation of human ESCs and iPSCs|
|Can be used conversion of fibroblasts to cardiomyocytes in combination with other small molecules|
|Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes|
|Fluorescent probe that selectively identifies undifferentiated iPS/ES cells|
|Accelerates maturation of hPSC-derived cardiomyocytes; synthetic double-stranded RNA (dsRNA)|
|Promotes cardiac differentiation; potent pan-JAK inhibitor|
|Component of 9C cocktail for conversion of fibroblasts to cardiomyocytes; potent and selective PDGFRβ inhibitor|
|Promotes maturation of hPSC-derived cardiomyocytes; thyroid hormone.|
|Wnt signaling inhibitor; induces differentiation of iPSCs to cardiomyocytes|
|Promotes cardiomyogenesis; potent tankyrase inhibitor|
|DNA methyltransferase inhibitor; induces cardiomyocyte differentiation in MSCs|
Tocris offers the following scientific literature for Cardiomyocyte Stem Cells to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.