IWP 4
Biological Activity
Potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
Technical Data
| M. Wt | 496.62 |
| Formula | C23H20N4O3S3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 686772-17-8 |
| PubChem ID | 2155264 |
| InChI Key | RHUJMHOIQBDFQR-UHFFFAOYSA-N |
| Smiles | O=C1C3=C(CCS3)N=C(SCC(NC4=NC(C=CC(C)=C5)=C5S4)=O)N1C2=C(OC)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.97 | 10mM with sonication |
Preparing Stock Solutions
The following data is based on the product molecular weight 496.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.01 mL | 10.07 mL | 20.14 mL |
| 5 mM | 0.4 mL | 2.01 mL | 4.03 mL |
| 10 mM | 0.2 mL | 1.01 mL | 2.01 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Lian et al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U.S.A. 109 E1848-57 PMID: 22645348
Chen et al (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat.Chem.Biol. 5 100 PMID: 19125156
Narytnyk et al (2014) Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons. Stem Cell Rev. 10 316 PMID: 24399192
If you know of a relevant reference for IWP 4, please let us know.
View Related Products by Target
Keywords: IWP 4, supplier, IWP4, potent, inhibitors, inhibits, Wnt, beta-catenin, β-catenin, b-catenin, cardiomyocytes, ESCs, iPSCs, stem, cells, embryonic, pluripotent, differentiation, Beta-catenin, Cardiomyocyte, Stem, Cells, ESCs, and, iPSC, Beta-catenin, Tocris Bioscience
Citations for IWP 4
Citations are publications that use Tocris products.
Currently there are no citations for IWP 4. Do you know of a great paper that uses IWP 4 from Tocris? If so please let us know.
Reviews for IWP 4
There are currently no reviews for this product. Be the first to review IWP 4 and earn rewards!
Have you used IWP 4?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and Europe
Submit a ReviewLiterature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Pathways for IWP 4
