IWP 4
Biological Activity
Potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
Technical Data
| M. Wt | 496.62 |
| Formula | C23H20N4O3S3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 686772-17-8 |
| PubChem ID | 2155264 |
| InChI Key | RHUJMHOIQBDFQR-UHFFFAOYSA-N |
| Smiles | O=C1C3=C(CCS3)N=C(SCC(NC4=NC(C=CC(C)=C5)=C5S4)=O)N1C2=C(OC)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.5 | 1 |
Preparing Stock Solutions
The following data is based on the product molecular weight 496.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.01 mM | 201.36 mL | 1006.81 mL | 2013.61 mL |
| 0.05 mM | 40.27 mL | 201.36 mL | 402.72 mL |
| 0.1 mM | 20.14 mL | 100.68 mL | 201.36 mL |
| 0.5 mM | 4.03 mL | 20.14 mL | 40.27 mL |
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References
References are publications that support the biological activity of the product.
Lian et al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U.S.A. 109 E1848-57 PMID: 22645348
Chen et al (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat.Chem.Biol. 5 100 PMID: 19125156
Narytnyk et al (2014) Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of DArgic neurons. Stem Cell Rev. 10 316 PMID: 24399192
If you know of a relevant reference for IWP 4, please let us know.
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Citations for IWP 4
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Reviews for IWP 4
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Pathways for IWP 4
