AM 80

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Cat.No. 3507 - AM 80 | C22H25NO3 | CAS No. 94497-51-5
Description: RARα agonist; anticancer
Alternative Names: Tamibarotene
Chemical Name: 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)

Biological Activity

Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo.

Technical Data

M. Wt 351.44
Formula C22H25NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 94497-51-5
PubChem ID 108143
InChI Key MUTNCGKQJGXKEM-UHFFFAOYSA-N
Smiles O=C(C3=CC=C(C(O)=O)C=C3)NC(C=C2)=CC1=C2C(C)(C)CCC(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 35.14 100
DMSO 17.57 50
ethanol 17.57 50

Preparing Stock Solutions

The following data is based on the product molecular weight 351.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.45 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kagechika et al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182 PMID: 3184125

Jimi et al (2007) RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 31 397 PMID: 17611697

Takenaga et al (2009) The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 32 225 PMID: 19182380


If you know of a relevant reference for AM 80, please let us know.

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Keywords: RARα RARalpha agonists anticancer Retinoic Acid Receptors AM80 Tamibarotene Retinoic Acid Receptors

1 Citation for AM 80

Citations are publications that use Tocris products. Selected citations for AM 80 include:

Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626 PMID: 27611191


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