Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 351.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.85 mL||14.23 mL||28.45 mL|
|5 mM||0.57 mL||2.85 mL||5.69 mL|
|10 mM||0.28 mL||1.42 mL||2.85 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kagechika et al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182 PMID: 3184125
Jimi et al (2007) RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 31 397 PMID: 17611697
Takenaga et al (2009) The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 32 225 PMID: 19182380
If you know of a relevant reference for AM 80, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: RARα RARalpha agonists anticancer Retinoic Acid Receptors AM80 Tamibarotene Retinoic Acid Receptors
1 Citation for AM 80
Citations are publications that use Tocris products. Selected citations for AM 80 include:
Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626 PMID: 27611191
Do you know of a great paper that uses AM 80 from Tocris? If so please let us know.