JNJ 10198409

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Cat.No. 6976 - JNJ 10198409 | C18H16FN3O2 | CAS No. 627518-40-5
Description: Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
Chemical Name: N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Protocols (1)
Literature (3)

Biological Activity

Potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in reprogramming of human fibroblasts into functional cardiomyocytes, within 9C cocktail.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Technical Data

M. Wt 325.34
Formula C18H16FN3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 627518-40-5
PubChem ID 9797370
InChI Key ZDNURMVOKAERHZ-UHFFFAOYSA-N
Smiles COC1=C(OC)C=C2C(CC3=C2NN=C3NC2=CC(F)=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.51 20
ethanol 32.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 325.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.37 mL 30.74 mL
5 mM 0.61 mL 3.07 mL 6.15 mL
10 mM 0.31 mL 1.54 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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References

References are publications that support the biological activity of the product.

Ho et al (2005) (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J.Med.Chem. 29 8163 PMID: 16366598

Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 352 1216 PMID: 27127239


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Citations for JNJ 10198409

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Protocols for JNJ 10198409

The following protocol features additional information for the use of JNJ 10198409 (Cat. No. 6976).

Literature in this Area

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