JNJ 10198409

Discontinued Product

6976 has been discontinued.

View all PDGFR products.
Description: Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
Chemical Name: N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews
Protocols (1)
Literature (1)

Biological Activity for JNJ 10198409

JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in transdifferentiation of human fibroblasts into functional cardiomyocytes, within 9C cocktail.

For more information about how JNJ 10198409 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Compound Libraries for JNJ 10198409

JNJ 10198409 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for JNJ 10198409

M. Wt 325.34
Formula C18H16FN3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 627518-40-5
PubChem ID 9797370
InChI Key ZDNURMVOKAERHZ-UHFFFAOYSA-N
Smiles COC1=C(OC)C=C2C(CC3=C2NN=C3NC2=CC(F)=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for JNJ 10198409

References are publications that support the biological activity of the product.

Ho et al (2005) (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J.Med.Chem. 29 8163 PMID: 16366598

Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 352 1216 PMID: 27127239

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Keywords: JNJ 10198409, JNJ 10198409 supplier, JNJ10198409, stem, cell, reprogramming, 9C, cocktail, cardiomyocytes, myocytes, platelet-derived, growth, factor, receptor, alpha, beta, inhibitors, inhibits, PDGFR, PDGFRb, PDGFRa, transdifferentiation, Src, Kinases, Other, Stem, Cell, Reprogramming, Cardiomyocyte, Cells, 6976, Tocris Bioscience

8 Citations for JNJ 10198409

Citations are publications that use Tocris products. Selected citations for JNJ 10198409 include:

Stephen H et al (2016) Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway. PLoS One 11 e0161445 PMID: 27776132

Anisur et al (2014) Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway. Dev Cell 31 747-60 PMID: 25482883

Donghong et al (2020) Anaplastic Lymphoma Kinase Regulates Internalization of the Dopamine D2 Receptor. Mol Pharmacol 97 123-131 PMID: 31734646

Zhihui et al (2011) Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein. J Biol Chem 286 39450-6 PMID: 21956113


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Protocols for JNJ 10198409

The following protocol features additional information for the use of JNJ 10198409 (Cat. No. 6976).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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