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Biological Activity for JNJ 10198409
JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in reprogramming of human fibroblasts into functional cardiomyocytes, within 9C cocktail.
Sold with the permission of Janssen Pharmaceutica N.V.
Compound Libraries for JNJ 10198409
Technical Data for JNJ 10198409
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 10198409
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for JNJ 10198409
The following data is based on the product molecular weight 325.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.07 mL||15.37 mL||30.74 mL|
|5 mM||0.61 mL||3.07 mL||6.15 mL|
|10 mM||0.31 mL||1.54 mL||3.07 mL|
|50 mM||0.06 mL||0.31 mL||0.61 mL|
References for JNJ 10198409
References are publications that support the biological activity of the product.
Ho et al (2005) (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J.Med.Chem. 29 8163 PMID: 16366598
Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 352 1216 PMID: 27127239
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Citations for JNJ 10198409
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Protocols for JNJ 10198409
The following protocol features additional information for the use of JNJ 10198409 (Cat. No. 6976).
Literature in this Area
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