Noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are ~5.0 and ~8.5 μM respectively). Inhibits NF-κB activation. Also reported to selectively activate Aurora kinase A-mediated phosphorylation of histone H3 and to inhibit protein SUMOylation. Exhibits antitumor, antimicrobial and antioxidant activity.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 348.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.87 mL||14.35 mL||28.69 mL|
|5 mM||0.57 mL||2.87 mL||5.74 mL|
|10 mM||0.29 mL||1.43 mL||2.87 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
References are publications that support the products' biological activity.
Kishore et al (2008) Specific small molecule activator of aurora kinase A induces autophosphorylation in a cell-free system. J.Med.Chem. 51 792 PMID: 18215015
Sung et al (2008) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the Blood 111 4880 PMID: 18349320
Balasubramanyam et al (2003) Small molecule modulators of histone acetyltransferase p300. J.Biol.Chem. 278 19134 PMID: 12624111
Fukuda et al (2009) Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem.Biol. 16 133 PMID: 19246003
If you know of a relevant reference for Anacardic acid, please let us know.
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Keywords: Anacardic acid, supplier, hat, histone, acetyltransferase, inhibitors, inhibits, nf-kb, nf-kappab, nf-κ, aurora, kinases, A, epigenetics, Aurora, Kinases, Histone, Acetyltransferases, Post-translational, Modifications, Other, Ligases, Histone, Acetyltransferases, Tocris Bioscience
1 Citation for Anacardic acid
Citations are publications that use Tocris products. Selected citations for Anacardic acid include:
Bonnaud et al (2015) Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. PLoS One 89 5996 PMID: 25810554
Do you know of a great paper that uses Anacardic acid from Tocris? If so please let us know.
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