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This is intended as a guide only; for full experimental details please read the reference provided.
Cao et al. converted human fibroblasts into functional cardiomyocytes using a 9C cocktail. The 9C-treated fibroblasts were transplanted into an infarcted mouse heart and converted to cardiomyocyte-like cells.
Human foreskin fibroblasts (HFF) were treated with 9C for 6 days and CIM for 5 days then transplanted into mice with infarcted hearts. When transplanted, 9C-treated fibroblasts were efficiently converted into cardiomyocyte-like cells.
|9C Medium||Cardiac Induction Medium|
|CHIR 99021 (Cat.No. 4423)||10 μM||CHIR 99021 (Cat.No. 4423)||12 μM|
|A 83-01 (Cat.No. 2939)||1 μM||BMP-4||25 ng/ml|
|SC1 (Cat.No. 4433)||1 μM||Activin A||10 ng/ml|
|OAC-2 (Cat.No. 6066)||5 μM||VEGF||10 ng/ml|
|Y-27632 (Cat.No. 1254)||10 μM|
|BIX 01294 (Cat.No. 3364)||1 μM|
|AS 8351 (Cat.No. 6044)||1 μM|
|SU 16f (Cat.No. 3304)||5 μM|
|JNJ 10198409||0.1 μM|