KY 02111

Pricing Availability Delivery Time Qty
Cat.No. 4731 - KY 02111 | C18H17ClN2O3S | CAS No. 1118807-13-8
Description: Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.

Compound Libraries

KY 02111 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 376.86
Formula C18H17ClN2O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1118807-13-8
PubChem ID 8582409
InChI Key LXFKEVQQSKQXPR-UHFFFAOYSA-N
Smiles O=C(CCC3=CC=C(OC)C(OC)=C3)NC2=NC1=CC=C(Cl)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.84 50

Preparing Stock Solutions

The following data is based on the product molecular weight 376.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.27 mL 26.54 mL
5 mM 0.53 mL 2.65 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Minami et al (2012) A small molecule that promotes cardiac differentiation of humam pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2 1448 PMID: 23103164


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Keywords: KY02111 stem cell differentiation cardiomyocytes human iPSCs ESCs Wnt signaling pathway inhibits inhibitors Cardiomyocyte Stem Cells

Citations for KY 02111

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for KY 02111

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