KY 02111

Pricing Availability   Qty
Description: Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Purity: ≥98% (HPLC)
Citations (2)
Literature (4)

Biological Activity for KY 02111

KY 02111 promotes differentiation of human ESCs and iPSCs into cardiomyocytes when used after day three in culture; differentiation efficiency increases when used after initial culture with CHIR 99021 (Cat. No. 4423). Induces downregulation of Wnt signaling target genes; inhibits canonical Wnt signaling in a manner distinct from other known Wnt inhibitors.

Compound Libraries for KY 02111

KY 02111 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for KY 02111

M. Wt 376.86
Formula C18H17ClN2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1118807-13-8
PubChem ID 8582409
Smiles O=C(CCC3=CC=C(OC)C(OC)=C3)NC2=NC1=CC=C(Cl)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KY 02111

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.84 50

Preparing Stock Solutions for KY 02111

The following data is based on the product molecular weight 376.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.31 mL 26.54 mL 53.07 mL
2.5 mM 1.06 mL 5.31 mL 10.61 mL
5 mM 0.53 mL 2.65 mL 5.31 mL
25 mM 0.11 mL 0.53 mL 1.06 mL

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Product Datasheets for KY 02111

Certificate of Analysis / Product Datasheet
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References for KY 02111

References are publications that support the biological activity of the product.

Minami et al (2012) A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2 1448 PMID: 23103164

If you know of a relevant reference for KY 02111, please let us know.

Keywords: KY 02111, KY 02111 supplier, KY02111, stem, cell, differentiation, cardiomyocytes, human, iPSCs, ESCs, Wnt, signaling, pathway, inhibits, inhibitors, Other, Signaling, Cardiomyocyte, Stem, Cells, and, iPSC, 4731, Tocris Bioscience

2 Citations for KY 02111

Citations are publications that use Tocris products. Selected citations for KY 02111 include:

Qui et al (2017) Rapamycin and CHIR99021 coordinate robust cardiomyocyte differentiation from human pluripotent stem cells via reducing p53-dependent apoptosis. J.Am.Heart Assoc. 6 e005295 PMID: 28971953

Chris et al (2020) Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour. F1000Res 8 1911 PMID: 32789000

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Literature in this Area

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