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Submit ReviewPoly(I:C)
Description: TLR3 agonist
Chemical Name: Polyinosinic-polycytidylic acid sodium salt
Biological Activity for Poly(I:C)
Poly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo. Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat. No. 6142). Transfection into NIT-1 β cells induces β-cell apoptosis.
To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.
Technical Data for Poly(I:C)
| Formula | (C10H13N4O8P)x.(C9H14N3O8P)x |
| Storage | Store at -20°C |
| CAS Number | 42424-50-0 |
| PubChem ID | 32744 |
| InChI Key | ACEVNMQDUCOKHT-ZLOOHWKQSA-N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Poly(I:C)
| Solubility | Soluble to 3 mg/ml in water |
Product Datasheets for Poly(I:C)
References for Poly(I:C)
References are publications that support the biological activity of the product.
Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616 PMID: 12960048
Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767 PMID: 15096480
West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476 PMID: 21525932
Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554
Biermann et al (2019) Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. Stem Cells 37 910 PMID: 31087611
Waele et al (2021) A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy. J.Exp.Clin.Cancer Res. 40 213 PMID: 34172082
If you know of a relevant reference for Poly(I:C), please let us know.
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Keywords: Poly(I:C), Poly(I:C) supplier, Poly(I:C), immunostimulant, toll-like, receptor, TLR, TLR3, agonist, inosinic, acid, cytidylic, double-stranded, RNA, dsRNA, synthetic, maternal, immune, activation, MIA, cardiomyocyte, differentiation, maturation, RIG-I, MDA-5, IFN, Notch, signaling, Toll-like, Receptors, Cardiomyocyte, Stem, Cells, 4287, Tocris Bioscience
3 Citations for Poly(I:C)
Citations are publications that use Tocris products. Selected citations for Poly(I:C) include:
Tachibana et al (2022) Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks. Comp.Biochem.Physiol.A Mol.Integr.Physiol. 269 111211 PMID: 35417747
Tröscher et al (2019) Microglial nodules provide the environment for pathogenic T cells in human encephalitis. Acta Neuropathol 137 619 PMID: 30663001
Yu et al (2018) Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol Cell 72 999 PMID: 30449722
Do you know of a great paper that uses Poly(I:C) from Tocris? Please let us know.
Reviews for Poly(I:C)
Average Rating: 5 (Based on 1 Review.)
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Poly IC.
By
shubham dubey on 12/22/2021
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: 16HBE
To activate TLR3
Literature in this Area
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Cancer Research Product Guide
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A collection of over 190 products for immunology research, the guide includes research tools for the study of:
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Pathways for Poly(I:C)
