Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant.
To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
References are publications that support the biological activity of the product.
Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616 PMID: 12960048
Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767 PMID: 15096480
West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476 PMID: 21525932
Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554
If you know of a relevant reference for Poly(I:C), please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Poly(I:C), Poly(I:C) supplier, Poly(I:C), immunostimulant, toll-like, receptor, TLR, TLR3, agonist, inosinic, acid, cytidylic, double-stranded, RNA, dsRNA, synthetic, Toll-like, Receptors, 4287, Tocris Bioscience
Citations for Poly(I:C)
Citations are publications that use Tocris products.
Currently there are no citations for Poly(I:C). Do you know of a great paper that uses Poly(I:C) from Tocris? Please let us know.
Reviews for Poly(I:C)
Average Rating: 5 (Based on 1 Review.)
Have you used Poly(I:C)?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
I used this product to activate TLR3.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.