Poly(I:C)

Pricing Availability Delivery Time Qty
Cat.No. 4287 - Poly(I:C) | (C10H13N4O8P)x.(C9H14N3O8P)x | CAS No. 24939-03-5
Description: TLR3 agonist
Chemical Name: Polyinosinic-polycytidylic acid sodium salt
Datasheet
Citations
Literature
Pathways

Biological Activity

Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant.

Technical Data

Formula (C10H13N4O8P)x.(C9H14N3O8P)x
Storage Store at -20°C
CAS Number 24939-03-5
PubChem ID 32744
InChI Key ACEVNMQDUCOKHT-ZLOOHWKQSA-N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3 0

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616 PMID: 12960048

Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767 PMID: 15096480

West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476 PMID: 21525932


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Keywords: Poly(I:C) immunostimulant toll-like receptor TLR TLR3 agonist inosinic acid cytidylic acid double-stranded RNA dsRNA synthetic Toll-like Receptors

Citations for Poly(I:C)

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for Poly(I:C)

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.

Protocols

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