Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant.
To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
References are publications that support the products' biological activity.
Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616 PMID: 12960048
Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767 PMID: 15096480
West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476 PMID: 21525932
Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554
If you know of a relevant reference for Poly(I:C), please let us know.
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Keywords: Poly(I:C), supplier, Poly(I:C), immunostimulant, toll-like, receptor, TLR, TLR3, agonist, inosinic, acid, cytidylic, acid, double-stranded, RNA, dsRNA, synthetic, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience
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