T 112

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Description: Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes
Chemical Name: 2-[2-(4-Bromophenyl)-1H-benzimidazol-6-yl]-2,3-dihydro-5-(4-morpholinyl)-1H-isoindol-1-one
Purity: ≥98% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for T 112

T 112 is an estrogen-related receptor gamma (ERRγ) agonist. Promotes maturation of hiPSC-derived cardiomyocytes. T 112 accelerates metabolic and sarcomere maturation in cardiomyocytes, as well as maturation of contractile and electrophysiological properties and ultrastructure organization, when used alone or in combination with other small molecules.

Licensing Information

Sold under license from Orizuru Therapeutics

Technical Data for T 112

M. Wt 489.37
Formula C25H21BrN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2376876-87-6
PubChem ID 151597503
Smiles BrC1=CC=C(C2=NC3=CC=C(N4CC5=CC(N6CCOCC6)=CC=C5C4=O)C=C3N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for T 112

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.89 10

Preparing Stock Solutions for T 112

The following data is based on the product molecular weight 489.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.43 mL 102.17 mL 204.34 mL
0.5 mM 4.09 mL 20.43 mL 40.87 mL
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

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References for T 112

References are publications that support the biological activity of the product.

Miki et al (2021) ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes. Nat.Commun. 12 3596 PMID: 34155205

If you know of a relevant reference for T 112, please let us know.

View Related Products by Product Action

View all Estrogen and Related Receptor Agonists

Keywords: T 112, T 112 supplier, T112, hiPSC, human, induced, pluripotent, stem, cells, cardiomyocyte, differentiation, maturation, estrogen, receptor, gamma, agonists, agonism, ERRgamma, γ, Estrogen, and, Related, Receptors, Cardiomyocyte, Stem, Cells, 7690, Tocris Bioscience

Citations for T 112

Citations are publications that use Tocris products.

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Literature in this Area

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Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for T 112

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.