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T 112 is an estrogen-related receptor gamma (ERRγ) agonist. Promotes maturation of hiPSC-derived cardiomyocytes. T 112 accelerates metabolic and sarcomere maturation in cardiomyocytes, as well as maturation of contractile and electrophysiological properties and ultrastructure organization, when used alone or in combination with other small molecules.
Sold under license from Orizuru Therapeutics
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 489.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||20.43 mL||102.17 mL||204.34 mL|
|0.5 mM||4.09 mL||20.43 mL||40.87 mL|
|1 mM||2.04 mL||10.22 mL||20.43 mL|
|5 mM||0.41 mL||2.04 mL||4.09 mL|
References are publications that support the biological activity of the product.
Miki et al (2021) ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes. Nat.Commun. 12 3596 PMID: 34155205
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Keywords: T 112, T 112 supplier, T112, hiPSC, human, induced, pluripotent, stem, cells, cardiomyocyte, differentiation, maturation, estrogen, receptor, gamma, agonists, agonism, ERRgamma, γ, Estrogen, and, Related, Receptors, Cardiomyocyte, Stem, Cells, 7690, Tocris Bioscience
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