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SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail.
For more information about how SU 16f may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)
SU 16f is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 386.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.59 mL||12.94 mL||25.88 mL|
|5 mM||0.52 mL||2.59 mL||5.18 mL|
|10 mM||0.26 mL||1.29 mL||2.59 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References are publications that support the biological activity of the product.
Sun et al (1999) Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120 PMID: 10602697
Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 1216 PMID: 27127239
If you know of a relevant reference for SU 16f, please let us know.
Keywords: SU 16f, SU 16f supplier, Potent, selective, PDGFRβ, PDGFRbeta, PDGFRb, inhibitors, inhibits, Platelet, Derived, Growth, Factor, Receptors, Tyrosine, Kinases, RTKs, SU16f, transdifferentiation, cardiomyocytes, PDGFR, Cardiomyocyte, Stem, Cells, 3304, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SU 16f include:
Novak et al (2023) PDGF inhibits BMP2-induced bone healing. NPJ Regen Med 8 3 PMID: 36631491
Chatterjee et al (2019) Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth. iScience 19 388 PMID: 31419632
Jiang et al (2017) A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion. Nat Commun 8 15926 PMID: 28649987
Andersen et al (2015) Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Proc Natl Acad Sci U S A 6 196 PMID: 26450135
Lee et al (2014) Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep 4 5853 PMID: 25068296
Do you know of a great paper that uses SU 16f from Tocris? Please let us know.
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The following protocol features additional information for the use of SU 16f (Cat. No. 3304).
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.