SU 16f

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Cat.No. 3304 - SU 16f | C24H22N2O3 | CAS No. 251356-45-3
Description: Potent and selective PDGFRβ inhibitor
Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Protocols (1)
Literature

Biological Activity

Potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM).

Compound Libraries

SU 16f is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 386.44
Formula C24H22N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 251356-45-3
PubChem ID 5329150
InChI Key APYYTEJNOZQZNA-MOSHPQCFSA-N
Smiles O=C2NC1=CC(C4=CC=CC=C4)=CC=C1/C2=C/C3=C(C)C(CCC(O)=O)=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 386.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.94 mL 25.88 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References

References are publications that support the biological activity of the product.

Sun et al (1999) Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120 PMID: 10602697


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View Related Products by Product Action

View all PDGFR Inhibitors

Keywords: SU 16f, SU 16f supplier, Potent, selective, PDGFRβ, PDGFRbeta, PDGFRb, inhibitors, inhibits, Platelet, Derived, Growth, Factor, Receptors, Tyrosine, Kinases, RTKs, SU16f, PDGFR, 3304, Tocris Bioscience

3 Citations for SU 16f

Citations are publications that use Tocris products. Selected citations for SU 16f include:

Andersen et al (2015) Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Proc Natl Acad Sci U S A 6 196 PMID: 26450135

Lee et al (2014) Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep 4 5853 PMID: 25068296

Jiang et al (2017) A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion. Nat Commun 8 15926 PMID: 28649987


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Reviews for SU 16f

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Protocols for SU 16f

The following protocol features additional information for the use of SU 16f (Cat. No. 3304).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Kinases Product Listing

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