SU 16f

Pricing Availability   Qty
Description: Potent and selective PDGFRβ inhibitor
Chemical Name: 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Purity: ≥98% (HPLC)
Citations (5)
Protocols (1)
Literature (1)

Biological Activity for SU 16f

SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail.

For more information about how SU 16f may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

Compound Libraries for SU 16f

SU 16f is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SU 16f

M. Wt 386.44
Formula C24H22N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 251356-45-3
PubChem ID 5329150
Smiles O=C2NC1=CC(C4=CC=CC=C4)=CC=C1/C2=C/C3=C(C)C(CCC(O)=O)=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SU 16f

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.64 100

Preparing Stock Solutions for SU 16f

The following data is based on the product molecular weight 386.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.94 mL 25.88 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Dilution Calculator

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References for SU 16f

References are publications that support the biological activity of the product.

Sun et al (1999) Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120 PMID: 10602697

Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 1216 PMID: 27127239

If you know of a relevant reference for SU 16f, please let us know.

View Related Products by Product Action

View all PDGFR Inhibitors

Keywords: SU 16f, SU 16f supplier, Potent, selective, PDGFRβ, PDGFRbeta, PDGFRb, inhibitors, inhibits, Platelet, Derived, Growth, Factor, Receptors, Tyrosine, Kinases, RTKs, SU16f, transdifferentiation, cardiomyocytes, PDGFR, Cardiomyocyte, Stem, Cells, 3304, Tocris Bioscience

5 Citations for SU 16f

Citations are publications that use Tocris products. Selected citations for SU 16f include:

Jiang et al (2017) A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion. Nat Commun 8 15926 PMID: 28649987

Chatterjee et al (2019) Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth. iScience 19 388 PMID: 31419632

Andersen et al (2015) Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Proc Natl Acad Sci U S A 6 196 PMID: 26450135

Lee et al (2014) Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep 4 5853 PMID: 25068296

Novak et al (2023) PDGF inhibits BMP2-induced bone healing. NPJ Regen Med 8 3 PMID: 36631491

Do you know of a great paper that uses SU 16f from Tocris? Please let us know.

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Protocols for SU 16f

The following protocol features additional information for the use of SU 16f (Cat. No. 3304).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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