You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 = 0.11 μM). Promotes conversion of fibroblasts to cardiomyocytes as part of 9C cocktail.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 386.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.59 mL||12.94 mL||25.88 mL|
|5 mM||0.52 mL||2.59 mL||5.18 mL|
|10 mM||0.26 mL||1.29 mL||2.59 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References are publications that support the biological activity of the product.
Sun et al (1999) Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120 PMID: 10602697
Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 1216 PMID: 27127239
If you know of a relevant reference for SU 16f, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SU 16f, SU 16f supplier, Potent, selective, PDGFRβ, PDGFRbeta, PDGFRb, inhibitors, inhibits, Platelet, Derived, Growth, Factor, Receptors, Tyrosine, Kinases, RTKs, SU16f, transdifferentiation, cardiomyocytes, PDGFR, Cardiomyocyte, Stem, Cells, 3304, Tocris Bioscience
4 Citations for SU 16f
Citations are publications that use Tocris products. Selected citations for SU 16f include:
Chatterjee et al (2019) Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth. iScience 19 388 PMID: 31419632
Jiang et al (2017) A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion. Nat Commun 8 15926 PMID: 28649987
Andersen et al (2015) Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Proc Natl Acad Sci U S A 6 196 PMID: 26450135
Lee et al (2014) Lymphatic endothelial cells support tumor growth in breast cancer. Sci Rep 4 5853 PMID: 25068296
Do you know of a great paper that uses SU 16f from Tocris? Please let us know.
Reviews for SU 16f
There are currently no reviews for this product. Be the first to review SU 16f and earn rewards!
Have you used SU 16f?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Protocols for SU 16f
The following protocol features additional information for the use of SU 16f (Cat. No. 3304).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.