PORCN

Porcupine (PORCN) is a membrane bound O-acyltransferase (MBOAT) that is involved in the acylation (palmitoylation) of Wnt proteins. Palmitoylation is essential for Wnt secretion and signaling, with PORCN inhibitors showing efficacy in inhibiting Wnt-driven tumorigenesis.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5279 IWP 12
Potent PORCN inhibitor; active in vivo
3533 IWP 2
PORCN inhibitor; inhibits Wnt processing and secretion
4992 IWP L6
Potent PORCN inhibitor
5148 Wnt-C59
Highly potent PORCN inhibitor

Related Targets

    Porcupine (PORCN) is a membrane bound O-acyltransferase (MBOAT) that is involved in the acylation (palmitoylation) of Wnt proteins. Palmitoylation is essential for Wnt secretion and signaling, with PORCN inhibitors showing efficacy in inhibiting Wnt-driven tumorigenesis.

    Palmitoylation is a post-translational modification where fatty acids, such as palmitic acid, are transferred to target proteins. PORCN selectively catalyzes the palmitoylation of Wnt proteins in the endoplasmic reticulum, a process which is essential for Wnt secretion and thus the induction of Wnt signaling. Interestingly PORCN has been shown to be the first acyltransferase that is itself palmitoylated. Palmitoylation of PORCN is thought to have a negative regulatory effect on Wnt secretion.

    Loss of PORCN function is associated with the disruption of Wnt signaling pathways, and pharmacological inhibition of Wnt has been shown to induce tumor regression in Wnt-dependent mammary tumors in mice. Therefore PORCN inhibitors have been postulated as therapeutics for the treatment of Wnt-driven cancers.

    Literature for PORCN

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
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    PORCN Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    PORCN Human PORCN NM_022825 Q9H237
    Mouse Porcn NM_023638 Q9JJJ7
    Rat Porcn NM_001173355 NP_001166826