Autophagy Inhibitors
| Cat. No. | Product Name / Activity |
|---|---|
| 4265 | AS 1842856 |
| Potent and selective Foxo1 inhibitor; suppresses autophagy | |
| 6324 | Autophinib |
| Potent VPS34 inhibitor | |
| 3771 | Azithromycin |
| Autophagy inhibitor; antibiotic | |
| 1334 | Bafilomycin A1 |
| H+-ATPase (vacuolar) inhibitor; also inhibits autophagy | |
| 1544 | (±)-Bay K 8644 |
| L-type Ca2+ channel activator; inhibits autophagy | |
| 4109 | Chloroquine diphosphate |
| Inhibits apoptosis and autophagy | |
| 2656 | Concanamycin A |
| H+-ATPase (vacuolar) inhibitor | |
| 4545 | E 64d |
| Cathepsin inhibitor; interferes with autolysosomal digestion | |
| 2473 | GW 4064 |
| Selective farnesoid X receptor (FXR) agonist; suppresses autophagy in nutrient-deprived hepatocytes | |
| 5648 | Hydroxychloroquine sulfate |
| Autophagy inhibitor; also TLR9 inhibitor | |
| 1130 | LY 294002 hydrochloride |
| Prototypical PI 3-kinase inhibitor; inhibits autophagic sequestration | |
| 3982 | Mdivi 1 |
| Autophagy inhibitor; also selective dynamin inhibitor | |
| 3977 | 3-Methyladenine |
| Class III PI 3-kinase inhibitor; also inhibits autophagy | |
| 5153 | ML 240 |
| ATP-competitive inhibitor of p97 ATPase; impairs autophagosome maturation | |
| 5134 | MRT 67307 dihydrochloride |
| Autophagy inhibitor; potent ULK inhibitor; also salt inducible kinase (SIK) inhibitor; | |
| 5067 | MRT 68601 hydrochloride |
| Potent TBK1 inhibitor; also inhibits autophagy | |
| 5780 | MRT 68921 dihydrochloride |
| Autophagy inhibitor; potent ULK inhibitor | |
| 6180 | NMS 873 |
| Potent and selective p97 ATPase (VCP) allosteric inhibitor | |
| 1228 | Nocodazole |
| Microtubule inhibitor; inhibits autophagosome-lysosome fusion | |
| 1190 | Pepstatin A |
| Protease inhibitor; interferes with autolysosomal digestion | |
| 1965 | Simvastatin |
| Autophagy inhibitor; HMG-CoA reductase inhibitor; also AMPK activator | |
| 5197 | Spautin 1 |
| Inhibits autophagy; USP10 and USP13 inhibitor | |
| 1097 | Taxol |
| Promotes assembly and inhibits disassembly of microtubules | |
| 1256 | Vinblastine sulfate |
| Disrupts microtubules; inhibits autophagosome maturation | |
| 1232 | Wortmannin |
| Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 |
Autophagy Scientific Review
Our Autophagy review summarizes the molecular mechanisms and physiology of autophagy, as well as the role of autophagy in certain disease states.
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Written by Patricia Boya and Patrice Codogno
Our Autophagy poster summarizes the molecular machinery, physiology and pathology of autophagy, and highlights chemical compounds that modulate autophagy.
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Written by Bram van Raam and Guy Salvesen
Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival.
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