Autophagy Inhibitors

Cat. No. Product Name / Activity
4265 AS 1842856
Potent and selective Foxo1 inhibitor; suppresses autophagy
6324 Autophinib
Potent VPS34 inhibitor
3771 Azithromycin
Autophagy inhibitor; antibiotic
1334 Bafilomycin A1
H+-ATPase (vacuolar) inhibitor; also inhibits autophagy
1544 (±)-Bay K 8644
L-type Ca2+ channel activator; inhibits autophagy
4109 Chloroquine diphosphate
Inhibits apoptosis and autophagy
2656 Concanamycin A
H+-ATPase (vacuolar) inhibitor
4417 DBeQ
Selective p97 ATPase inhibitor; blocks autophagosome maturation
4545 E 64d
Cathepsin inhibitor; interferes with autolysosomal digestion
2473 GW 4064
Selective farnesoid X receptor (FXR) agonist; suppresses autophagy in nutrient-deprived hepatocytes
5648 Hydroxychloroquine sulfate
Autophagy inhibitor; also TLR9 inhibitor
1130 LY 294002 hydrochloride
Prototypical PI 3-kinase inhibitor; inhibits autophagic sequestration
3982 Mdivi 1
Autophagy inhibitor; also selective dynamin inhibitor
3977 3-Methyladenine
Class III PI 3-kinase inhibitor; also inhibits autophagy
5153 ML 240
ATP-competitive inhibitor of p97 ATPase; impairs autophagosome maturation
5134 MRT 67307 dihydrochloride
Autophagy inhibitor; potent ULK inhibitor; also salt inducible kinase (SIK) inhibitor;
5067 MRT 68601 hydrochloride
Potent TBK1 inhibitor; also inhibits autophagy
5780 MRT 68921 dihydrochloride
Autophagy inhibitor; potent ULK inhibitor
6180 NMS 873
Potent and selective p97 ATPase (VCP) allosteric inhibitor
1228 Nocodazole
Microtubule inhibitor; inhibits autophagosome-lysosome fusion
1190 Pepstatin A
Protease inhibitor; interferes with autolysosomal digestion
1965 Simvastatin
Autophagy inhibitor; HMG-CoA reductase inhibitor; also AMPK activator
5197 Spautin 1
Inhibits autophagy; USP10 and USP13 inhibitor
1097 Taxol
Promotes assembly and inhibits disassembly of microtubules
1256 Vinblastine sulfate
Disrupts microtubules; inhibits autophagosome maturation
1232 Wortmannin
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
4686 Xanthohumol
p97 ATPase (VCP) inhibitor; impairs autophagosome maturation