ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.61 mL||63.06 mL||126.12 mL|
|1 mM||2.52 mL||12.61 mL||25.22 mL|
|2 mM||1.26 mL||6.31 mL||12.61 mL|
|10 mM||0.25 mL||1.26 mL||2.52 mL|
References are publications that support the biological activity of the product.
Chou et al (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8 297 PMID: 23316025
If you know of a relevant reference for ML 240, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 240, ML 240 supplier, ML240, ATP, competitive, inhibitors, AAA, ATPases, p97, VCP, valosin, autophagy, inhibits, Autophagy, Translocation,, Exocytosis, &, Endocytosis, Other, ER, stress/UPR, ATPase, 5153, Tocris Bioscience
Citations for ML 240
Citations are publications that use Tocris products.
Currently there are no citations for ML 240. Do you know of a great paper that uses ML 240 from Tocris? Please let us know.
Reviews for ML 240
There are currently no reviews for this product. Be the first to review ML 240 and earn rewards!
Have you used ML 240?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.