ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.61 mL||63.06 mL||126.12 mL|
|1 mM||2.52 mL||12.61 mL||25.22 mL|
|2 mM||1.26 mL||6.31 mL||12.61 mL|
|10 mM||0.25 mL||1.26 mL||2.52 mL|
References are publications that support the biological activity of the product.
Chou et al (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8 297 PMID: 23316025
If you know of a relevant reference for ML 240, please let us know.
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Keywords: ML 240, ML 240 supplier, ML240, ATP, competitive, inhibitors, AAA, ATPases, p97, VCP, valosin, autophagy, inhibits, Autophagy, Translocation,, Exocytosis, &, Endocytosis, Other, ER, stress/UPR, ATPase, 5153, Tocris Bioscience
Citations for ML 240
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Literature in this Area
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Cancer Metabolism Poster
Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.