ML 240

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Cat.No. 5153 - ML 240 | C23H20N6O | CAS No. 1346527-98-7
Description: ATP-competitive inhibitor of p97 ATPase
Chemical Name: 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.

Technical Data

M. Wt 396.44
Formula C23H20N6O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1346527-98-7
PubChem ID 49830258
InChI Key NHAMBLRUUJAFOY-UHFFFAOYSA-N
Smiles NC1=NC4=C(C=CC=C4)N1C3=NC2=C(OC)C=CC=C2C(NCC5=CC=CC=C5)=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.93 20

Preparing Stock Solutions

The following data is based on the product molecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.61 mL 63.06 mL 126.12 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
2 mM 1.26 mL 6.31 mL 12.61 mL
10 mM 0.25 mL 1.26 mL 2.52 mL

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References

References are publications that support the biological activity of the product.

Chou et al (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8 297 PMID: 23316025


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View all p97 ATPase Inhibitors

Keywords: ML 240, ML 240 supplier, ML240, ATP, competitive, inhibitors, AAA, ATPases, p97, VCP, valosin, autophagy, inhibits, Autophagy, Translocation,, Exocytosis, &, Endocytosis, Other, ER, stress/UPR, ATPase, 5153, Tocris Bioscience

Citations for ML 240

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