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Biological Activity for Autophinib
Autophinib is a potent VPS34 inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).
Compound Libraries for Autophinib
Technical Data for Autophinib
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Autophinib
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Autophinib
The following data is based on the product molecular weight 346.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||14.42 mL||72.1 mL||144.2 mL|
|1 mM||2.88 mL||14.42 mL||28.84 mL|
|2 mM||1.44 mL||7.21 mL||14.42 mL|
|10 mM||0.29 mL||1.44 mL||2.88 mL|
References for Autophinib
References are publications that support the biological activity of the product.
Richters et al (2015) Identification and further development of potent TBK1 inhibitors. ACS Chem Biol. 10 289 PMID: 25540906
Robke et al (2017) Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew.Chem.Int.Ed.Engl. 56 8153 PMID: 28544137
If you know of a relevant reference for Autophinib, please let us know.
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Keywords: Autophinib, Autophinib supplier, Potent, autophagy, inhibitors, inhibits, VPS34, vacuolar, protein, sorting, 34, PI, 3-K, 3-kinase, Autophagy, 3-Kinase, 6324, Tocris Bioscience
Citations for Autophinib
Citations are publications that use Tocris products.
Currently there are no citations for Autophinib. Do you know of a great paper that uses Autophinib from Tocris? Please let us know.
Reviews for Autophinib
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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