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Potent VPS34 inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 346.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||14.42 mL||72.1 mL||144.2 mL|
|1 mM||2.88 mL||14.42 mL||28.84 mL|
|2 mM||1.44 mL||7.21 mL||14.42 mL|
|10 mM||0.29 mL||1.44 mL||2.88 mL|
References are publications that support the biological activity of the product.
Richters et al (2015) Identification and further development of potent TBK1 inhibitors. ACS Chem Biol. 10 289 PMID: 25540906
Robke et al (2017) Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew.Chem.Int.Ed.Engl. 56 8153 PMID: 28544137
If you know of a relevant reference for Autophinib, please let us know.
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Keywords: Autophinib, Autophinib supplier, Potent, autophagy, inhibitors, inhibits, VPS34, vacuolar, protein, sorting, 34, PI, 3-K, 3-kinase, Autophagy, 3-Kinase, 6324, Tocris Bioscience
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