Autophinib

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Cat.No. 6324 - Autophinib | C14H11ClN6O3 | CAS No. 1644443-47-9
Description: Potent VPS34 inhibitor
Chemical Name: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Potent VPS34 inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).

Compound Libraries

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Technical Data

M. Wt 346.73
Formula C14H11ClN6O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1644443-47-9
PubChem ID 129626605
InChI Key CEUMAXLRGBKFQP-UHFFFAOYSA-N
Smiles CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.93 20

Preparing Stock Solutions

The following data is based on the product molecular weight 346.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.42 mL 72.1 mL 144.2 mL
1 mM 2.88 mL 14.42 mL 28.84 mL
2 mM 1.44 mL 7.21 mL 14.42 mL
10 mM 0.29 mL 1.44 mL 2.88 mL

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References

References are publications that support the biological activity of the product.

Richters et al (2015) Identification and further development of potent TBK1 inhibitors. ACS Chem Biol. 10 289 PMID: 25540906

Robke et al (2017) Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew.Chem.Int.Ed.Engl. 56 8153 PMID: 28544137


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Citations for Autophinib

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Literature in this Area

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